Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1121242..1122040 Replicon chromosome
Accession NZ_CP095514
Organism Escherichia coli strain GN02323

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag MW403_RS05330 Protein ID WP_000854730.1
Coordinates 1121242..1121619 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag MW403_RS05335 Protein ID WP_001285481.1
Coordinates 1121666..1122040 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW403_RS05305 (1116498) 1116498..1117902 + 1405 Protein_1019 IS66 family transposase -
MW403_RS05310 (1118156) 1118156..1119289 - 1134 WP_000555401.1 IS110-like element ISEc45 family transposase -
MW403_RS05315 (1119350) 1119350..1119538 + 189 Protein_1021 IS66 family transposase -
MW403_RS05320 (1119686) 1119686..1120674 + 989 Protein_1022 IS630 family transposase -
MW403_RS05325 (1120753) 1120753..1121245 - 493 Protein_1023 DUF5983 family protein -
MW403_RS05330 (1121242) 1121242..1121619 - 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
MW403_RS05335 (1121666) 1121666..1122040 - 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MW403_RS05340 (1122090) 1122090..1122734 - 645 WP_000086761.1 hypothetical protein -
MW403_RS05345 (1122753) 1122753..1122974 - 222 WP_000692315.1 DUF987 domain-containing protein -
MW403_RS05350 (1123037) 1123037..1123513 - 477 WP_001313574.1 RadC family protein -
MW403_RS05355 (1123529) 1123529..1124002 - 474 WP_001313575.1 antirestriction protein -
MW403_RS05360 (1124096) 1124096..1124341 - 246 WP_001164966.1 hypothetical protein -
MW403_RS05365 (1124341) 1124341..1125162 - 822 WP_001234359.1 DUF932 domain-containing protein -
MW403_RS05370 (1125262) 1125262..1125495 - 234 WP_001213776.1 DUF905 family protein -
MW403_RS05375 (1125613) 1125613..1126065 - 453 WP_000682723.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T242142 WP_000854730.1 NZ_CP095514:c1121619-1121242 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T242142 NZ_OW052188:719922-720359 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT242142 WP_001285481.1 NZ_CP095514:c1122040-1121666 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT242142 NZ_OW052188:719671-719925 [Mycobacterium tuberculosis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References