Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 734709..735544 Replicon chromosome
Accession NZ_CP095514
Organism Escherichia coli strain GN02323

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag MW403_RS03460 Protein ID WP_000854759.1
Coordinates 735167..735544 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag MW403_RS03455 Protein ID WP_001295723.1
Coordinates 734709..735077 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW403_RS03430 (731824) 731824..732019 + 196 Protein_654 DUF905 family protein -
MW403_RS03435 (732137) 732137..732955 + 819 WP_001234738.1 DUF932 domain-containing protein -
MW403_RS03440 (733297) 733297..733770 + 474 WP_001350782.1 antirestriction protein -
MW403_RS03445 (733786) 733786..734262 + 477 WP_001186775.1 RadC family protein -
MW403_RS03450 (734325) 734325..734546 + 222 WP_000692345.1 DUF987 domain-containing protein -
MW403_RS03455 (734709) 734709..735077 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MW403_RS03460 (735167) 735167..735544 + 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
MW403_RS03465 (735541) 735541..736029 + 489 WP_000761690.1 DUF5983 family protein -
MW403_RS03470 (736046) 736046..736222 + 177 WP_000839286.1 DUF957 domain-containing protein -
MW403_RS03475 (736328) 736328..736477 + 150 Protein_663 hypothetical protein -
MW403_RS03480 (736844) 736844..737020 + 177 Protein_664 helix-turn-helix domain-containing protein -
MW403_RS03485 (737811) 737811..739433 + 1623 WP_001295726.1 Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 721016..747190 26174


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T242137 WP_000854759.1 NZ_CP095514:735167-735544 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T242137 NZ_OW052188:c238436-238062 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT242137 WP_001295723.1 NZ_CP095514:734709-735077 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT242137 NZ_OW052188:c238630-238433 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References