Detailed information of TA system TA242102

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1087290..1088124
• Replicon: chromosome
• Accession: NZ_CP095510
• Organism: Escherichia coli strain GN02270

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A8E0IX31
• Locus tag: MW401_RS05250
• Protein ID: WP_000854689.1
• Coordinates: 1087290..1087667 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E0IVP8
• Locus tag: MW401_RS05255
• Protein ID: WP_001285599.1
• Coordinates: 1087744..1088124 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MW401_RS05220 (1083684)	1083684..1083854	-	171	Protein_1015	IS110 family transposase	-
MW401_RS05225 (1084271)	1084271..1085204	-	934	Protein_1016	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
MW401_RS05230 (1085197)	1085197..1085592	-	396	WP_000208381.1	DUF6088 family protein	-
MW401_RS05235 (1085661)	1085661..1086506	-	846	WP_001446750.1	DUF4942 domain-containing protein	-
MW401_RS05240 (1086591)	1086591..1086788	-	198	WP_000839250.1	DUF957 domain-containing protein	-
MW401_RS05245 (1086805)	1086805..1087293	-	489	WP_000761698.1	DUF5983 family protein	-
MW401_RS05250 (1087290)	1087290..1087667	-	378	WP_000854689.1	TA system toxin CbtA family protein	Toxin
MW401_RS05255 (1087744)	1087744..1088124	-	381	WP_001285599.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
MW401_RS05260 (1088174)	1088174..1088818	-	645	WP_000086757.1	hypothetical protein	-
MW401_RS05265 (1088837)	1088837..1089058	-	222	WP_000692315.1	DUF987 domain-containing protein	-
MW401_RS05270 (1089121)	1089121..1089597	-	477	WP_001186761.1	RadC family protein	-
MW401_RS05275 (1089613)	1089613..1090086	-	474	WP_001538139.1	antirestriction protein	-
MW401_RS05280 (1090350)	1090350..1091171	-	822	WP_001234555.1	DUF932 domain-containing protein	-
MW401_RS05285 (1091350)	1091350..1091439	-	90	WP_225385657.1	DUF905 family protein	-
MW401_RS05290 (1091582)	1091582..1092037	-	456	WP_001309747.1	IrmA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1083684..1083839	155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14042.07 Da
• Isoelectric Point: 9.1510

>T242102 WP_000854689.1 NZ_CP095510:c1087667-1087290 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Nucleotide

• Length: 378 bp

>T242102 NZ_OV753987:4001931-4002149 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13984.78 Da
• Isoelectric Point: 5.0823

>AT242102 WP_001285599.1 NZ_CP095510:c1088124-1087744 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLLQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT242102 NZ_OV753987:4001530-4001904 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG