Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 42380..43968 Replicon chromosome
Accession NZ_CP095505
Organism Escherichia coli strain GN02050

Toxin (Protein)


Gene name hipA Uniprot ID A0A8E0MJW1
Locus tag MW398_RS01055 Protein ID WP_021524177.1
Coordinates 42380..43702 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag MW398_RS01060 Protein ID WP_001332145.1
Coordinates 43702..43968 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW398_RS01030 (38402) 38402..39112 - 711 WP_001195181.1 fimbria/pilus periplasmic chaperone -
MW398_RS01035 (39474) 39474..40037 - 564 WP_001327671.1 type 1 fimbrial major subunit FimA -
MW398_RS01040 (40462) 40462..40569 + 108 Protein_32 hypothetical protein -
MW398_RS01045 (40813) 40813..41249 - 437 Protein_33 NAD(P)H-binding protein -
MW398_RS01050 (41220) 41220..41987 + 768 WP_021538603.1 LysR substrate-binding domain-containing protein -
MW398_RS01055 (42380) 42380..43702 - 1323 WP_021524177.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
MW398_RS01060 (43702) 43702..43968 - 267 WP_001332145.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
MW398_RS01065 (44276) 44276..45034 + 759 WP_001286588.1 trans-aconitate 2-methyltransferase -
MW398_RS01070 (45038) 45038..45952 - 915 WP_001306069.1 bestrophin family protein -
MW398_RS01075 (46149) 46149..47600 - 1452 WP_000854636.1 tagaturonate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49384.16 Da        Isoelectric Point: 8.9380

>T242067 WP_021524177.1 NZ_CP095505:c43702-42380 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRGRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

>T242067 NZ_OV350343:c472130-471852 [Halomonas sp. TD01]
ATGATTAAATCATTCCGCCACAAGGGACTCAAGCGGTTCTACGCTAGTGGCAGCACCGCTGGTATACAGGCGGATCATGC
CAAGAAATTGCGTATGCAGCTTGCCGCTCTGGACACGGCCGTGTCAGTAGAAGATATGGATATCCCTGGTTTTAGGCTCC
ACCCGTTGAAGGGGAGAGACAAAGCGCGGTGGTCAATTTGGATCAACGGAAATTGGCGCATGACGTTCGAATTTCGAGAT
GGCAACGCGTACATTCTTGATTATGAGGATTATCACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.44 Da        Isoelectric Point: 6.2267

>AT242067 WP_001332145.1 NZ_CP095505:c43968-43702 [Escherichia coli]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp

>AT242067 NZ_OV350343:c471852-471559 [Halomonas sp. TD01]
ATGACGATGCATAATCCGCCGCATCCCGGCGAATTTATTCGGGAAGTGTACCTAGAACCTTTTGGTATCAGCTCCCGTCA
GCTTGCTTCCAACTTGGGCGTTTCACCATCCACCTTGTCACGGTTGCTCAAAGGGGATAGTGGCATTAGCCCCGAAATGT
CTTTGCGCTTGTCGAAGGTTCTCGGACGTACCCCGGAGAGCTGGCTATCAATGCAGGACATGTATGACCTATGGATGGCT
CGCAGCACAATTAATTTGGACGACCTGCAGCCATTGGACTTTGAGGCCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References