Detailed information of TA system TA242060

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 186594..187231
• Replicon: chromosome
• Accession: NZ_CP095498
• Organism: Burkholderia cepacia strain BRDJ

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MW307_RS23085
• Protein ID: WP_119338719.1
• Coordinates: 186830..187231 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A4S5D069
• Locus tag: MW307_RS23080
• Protein ID: WP_059528333.1
• Coordinates: 186594..186830 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MW307_RS23065	182186..183217	+	1032	WP_027788682.1	helix-turn-helix domain-containing protein	-
MW307_RS23070	183338..184480	-	1143	WP_247040045.1	ADP-heptose--LPS heptosyltransferase	-
MW307_RS23075	184477..186180	-	1704	WP_247040046.1	thiamine pyrophosphate-binding protein	-
MW307_RS23080	186594..186830	+	237	WP_059528333.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MW307_RS23085	186830..187231	+	402	WP_119338719.1	type II toxin-antitoxin system VapC family toxin	Toxin
MW307_RS23090	187318..188706	-	1389	WP_027788676.1	L-serine ammonia-lyase	-
MW307_RS23095	188737..189873	-	1137	WP_027788675.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-120)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14968.11 Da
• Isoelectric Point: 5.1955

>T242060 WP_119338719.1 NZ_CP095498:186830-187231 [Burkholderia cepacia]
MARYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTVCVRPARERSNLAALIEDIPVAPFDAPAAQA
YGPVREATRDRKKDHLDKLIAAHAVSLDVVLVTNNERDFASYPGVRLENWLSD

Nucleotide

• Length: 402 bp

>T242060 NZ_OV100759:116256-116528 [Aggregatibacter sp. Marseille-P9115]
ATGAAAATTAGCTTTACTAAAGACTATAAACGCGATCTCAAACGATTAGCCAATCAACCCGAAATATTACTTTCTGCCGA
AATGATTGATGTTATGCATCATTTGCTAAACGGCAAGAATCTTCCCGAAAAATACAAGGATCATGCATTGTCCGGAAATT
GGAAAGGGTTTCGAGATTGCCATATTAAAAATGATCTAGTGTTGATTTACCACGTAAATAATGAAGGACTCACTTTGGTT
AGACTCAACACCCATTCTGAAGTTTTTCGCTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8983.13 Da
• Isoelectric Point: 5.7252

>AT242060 WP_059528333.1 NZ_CP095498:186594-186830 [Burkholderia cepacia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPMRRPLTGVLEKFAKFGPDFMAEGRGDHEQADREGL

Nucleotide

• Length: 237 bp

>AT242060 NZ_OV100759:115983-116255 [Aggregatibacter sp. Marseille-P9115]
ATGACTTCATATACTTTTCGATTAGATCCTGAATTAAAAGAGCAGGCCTTTTCCGTTTTCAGAAGCTACGGATTAAACCC
GGCTCAGGCACTAAAAATGATTTTACAACAAGTGGTTTCGACAAAATCTATTCCTGTTCAGTTAGATTATCAACCGAATG
AAACAACGATCCGCGCTATGGAAGATGCATTAAGTGGAAAAGTGGAAAGCGTAGAAACTGAGAACGTAGAGGAGCTGATT
AAAAAAATGCAACGTGTCGCAAACGAGGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A4S5D069