Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2726982..2728203 Replicon chromosome
Accession NZ_CP095497
Organism Burkholderia cepacia strain BRDJ

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MW307_RS18705 Protein ID WP_091923585.1
Coordinates 2727622..2728203 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MW307_RS18700 Protein ID WP_119338154.1
Coordinates 2726982..2727539 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW307_RS18675 2722379..2723110 - 732 WP_027789599.1 ribonuclease T2 -
MW307_RS18680 2723341..2723730 + 390 WP_119338156.1 OsmC family protein -
MW307_RS18685 2723812..2724390 - 579 WP_119338155.1 hypothetical protein -
MW307_RS18690 2724487..2725890 - 1404 WP_060198020.1 hypothetical protein -
MW307_RS18695 2726250..2726927 + 678 WP_027789603.1 hypothetical protein -
MW307_RS18700 2726982..2727539 + 558 WP_119338154.1 helix-turn-helix transcriptional regulator Antitoxin
MW307_RS18705 2727622..2728203 + 582 WP_091923585.1 HD domain-containing protein Toxin
MW307_RS18710 2728259..2728987 + 729 WP_119338153.1 class I SAM-dependent methyltransferase -
MW307_RS18715 2729268..2730461 + 1194 WP_119338152.1 macrolide transporter subunit MacA -
MW307_RS18720 2730464..2732524 + 2061 WP_060173636.1 MacB family efflux pump subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21242.83 Da        Isoelectric Point: 5.0821

>T242059 WP_091923585.1 NZ_CP095497:2727622-2728203 [Burkholderia cepacia]
MNPDTIHARLAFLREAERLKNVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTAPLDPVQRDEIVALWDEYEAAASPEARAAKAFDKLETILQHTQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDAGGQHA

Download         Length: 582 bp

>T242059 NZ_OV049814:c45315-45010 [Klebsiella pneumoniae]
ATGCAGTTCACCGTCTACGAATACACACGCGAGAGCCATTATCGTCTTTTTGTGGATGTGCAGAGCGACATTGTCGAGAC
GCCTGGGCGACGCATAGTGATCCCGTTGCTGGAATCGCACCACTTATCAGAAAAGGTTAATCAGCAGCTTTTCCCGGTGG
TTAGCGTCAATGGGAAAGAATACCGTGCCGTGACTTCCGAATTATCCGGAGTCTCTGTCAGTGTCATCGGCGACGCTGTG
GCCGATCTCAGCCATGAGGCAAATGCCATTAAAAATGCCCTGAACCTGATGTTCTGGGGCATTTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20057.96 Da        Isoelectric Point: 8.8097

>AT242059 WP_119338154.1 NZ_CP095497:2726982-2727539 [Burkholderia cepacia]
MSASPLHAPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPDERATAERLLAAHLDSAGDHALARLVAG
SAGRIHLVCDLTHRLLACSPARAAEFSQPLSMLLGTSLWRYATPEIVRMEAALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAARLVETL

Download         Length: 558 bp

>AT242059 NZ_OV049814:c45533-45315 [Klebsiella pneumoniae]
ATGAAACACAGAGCCAGCGTCACAGTAGACAAGGAACATTATCTGGAATTACTCGCGGCAGGCGTGAATATTTCGGGACT
GGTGAATGAGGCTATCGGACGGGAAGCCCGGCGCATCCAGGCTGAACGCTGGAAAGCAGAGAACCGGGAAGGGATGGAAG
AGGTAGCGAATTTCATCGCGCAGCACGGCTCTTTTGCCGACGAAAACCGGAGCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References