Detailed information of TA system TA242059

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2726982..2728203
• Replicon: chromosome
• Accession: NZ_CP095497
• Organism: Burkholderia cepacia strain BRDJ

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MW307_RS18705
• Protein ID: WP_091923585.1
• Coordinates: 2727622..2728203 (+)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MW307_RS18700
• Protein ID: WP_119338154.1
• Coordinates: 2726982..2727539 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MW307_RS18675	2722379..2723110	-	732	WP_027789599.1	ribonuclease T2	-
MW307_RS18680	2723341..2723730	+	390	WP_119338156.1	OsmC family protein	-
MW307_RS18685	2723812..2724390	-	579	WP_119338155.1	hypothetical protein	-
MW307_RS18690	2724487..2725890	-	1404	WP_060198020.1	hypothetical protein	-
MW307_RS18695	2726250..2726927	+	678	WP_027789603.1	hypothetical protein	-
MW307_RS18700	2726982..2727539	+	558	WP_119338154.1	helix-turn-helix transcriptional regulator	Antitoxin
MW307_RS18705	2727622..2728203	+	582	WP_091923585.1	HD domain-containing protein	Toxin
MW307_RS18710	2728259..2728987	+	729	WP_119338153.1	class I SAM-dependent methyltransferase	-
MW307_RS18715	2729268..2730461	+	1194	WP_119338152.1	macrolide transporter subunit MacA	-
MW307_RS18720	2730464..2732524	+	2061	WP_060173636.1	MacB family efflux pump subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-173)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21242.83 Da
• Isoelectric Point: 5.0821

>T242059 WP_091923585.1 NZ_CP095497:2727622-2728203 [Burkholderia cepacia]
MNPDTIHARLAFLREAERLKNVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTAPLDPVQRDEIVALWDEYEAAASPEARAAKAFDKLETILQHTQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDAGGQHA

Nucleotide

• Length: 582 bp

>T242059 NZ_OV049814:c45315-45010 [Klebsiella pneumoniae]
ATGCAGTTCACCGTCTACGAATACACACGCGAGAGCCATTATCGTCTTTTTGTGGATGTGCAGAGCGACATTGTCGAGAC
GCCTGGGCGACGCATAGTGATCCCGTTGCTGGAATCGCACCACTTATCAGAAAAGGTTAATCAGCAGCTTTTCCCGGTGG
TTAGCGTCAATGGGAAAGAATACCGTGCCGTGACTTCCGAATTATCCGGAGTCTCTGTCAGTGTCATCGGCGACGCTGTG
GCCGATCTCAGCCATGAGGCAAATGCCATTAAAAATGCCCTGAACCTGATGTTCTGGGGCATTTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20057.96 Da
• Isoelectric Point: 8.8097

>AT242059 WP_119338154.1 NZ_CP095497:2726982-2727539 [Burkholderia cepacia]
MSASPLHAPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPDERATAERLLAAHLDSAGDHALARLVAG
SAGRIHLVCDLTHRLLACSPARAAEFSQPLSMLLGTSLWRYATPEIVRMEAALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT242059 NZ_OV049814:c45533-45315 [Klebsiella pneumoniae]
ATGAAACACAGAGCCAGCGTCACAGTAGACAAGGAACATTATCTGGAATTACTCGCGGCAGGCGTGAATATTTCGGGACT
GGTGAATGAGGCTATCGGACGGGAAGCCCGGCGCATCCAGGCTGAACGCTGGAAAGCAGAGAACCGGGAAGGGATGGAAG
AGGTAGCGAATTTCATCGCGCAGCACGGCTCTTTTGCCGACGAAAACCGGAGCTGGTGA