Detailed information of TA system TA242058

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2566204..2566859
• Replicon: chromosome
• Accession: NZ_CP095497
• Organism: Burkholderia cepacia strain BRDJ

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: U2HGC0
• Locus tag: MW307_RS18000
• Protein ID: WP_021158162.1
• Coordinates: 2566204..2566623 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MW307_RS18005
• Protein ID: WP_119338641.1
• Coordinates: 2566620..2566859 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MW307_RS17975	2561509..2562303	+	795	WP_119338643.1	AraC family transcriptional regulator	-
MW307_RS17980	2562623..2563576	+	954	WP_119338644.1	DMT family transporter	-
MW307_RS17985	2563761..2564309	+	549	WP_059698680.1	hypothetical protein	-
MW307_RS17990	2564405..2564539	-	135	WP_021158165.1	entericidin A/B family lipoprotein	-
MW307_RS17995	2564773..2566068	+	1296	WP_027789492.1	aspartate carbamoyltransferase	-
MW307_RS18000	2566204..2566623	-	420	WP_021158162.1	type II toxin-antitoxin system VapC family toxin	Toxin
MW307_RS18005	2566620..2566859	-	240	WP_119338641.1	plasmid stability protein	Antitoxin
MW307_RS18010	2567169..2569415	+	2247	WP_060086295.1	TonB-dependent siderophore receptor	-
MW307_RS18015	2569419..2570174	+	756	WP_119338640.1	tetratricopeptide repeat protein	-
MW307_RS18020	2570171..2570854	+	684	WP_119338639.1	Fe2+-dependent dioxygenase	-
MW307_RS18025	2570944..2571183	+	240	WP_011659184.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
MW307_RS18030	2571180..2571575	+	396	WP_027789497.1	type II toxin-antitoxin system VapC family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15212.57 Da
• Isoelectric Point: 5.9052

>T242058 WP_021158162.1 NZ_CP095497:c2566623-2566204 [Burkholderia cepacia]
MILVDTNVISEPLRREPNAAVIEWLDAQNVETLFLAAISLAEIRLGVAVLPEGRRREWLHQSIEQRVLPLFRGRILPFDD
AASKAYASLRARARAAGVAIAPSDGFIAGTAEANGLIVATRDVTPFEAMGIRVIDPWAR

Nucleotide

• Length: 420 bp

>T242058 NZ_OV049813:c3406-2990 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCGTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAATTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8657.85 Da
• Isoelectric Point: 6.4643

>AT242058 WP_119338641.1 NZ_CP095497:c2566859-2566620 [Burkholderia cepacia]
MPVITVRNLSDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTMLAAIGREAGGFDFDAQRDKTPADPMSFE

Nucleotide

• Length: 240 bp

>AT242058 NZ_OV049813:c3633-3403 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGTGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGCGAGGATGTGGTCAGCGACGAAGGACGCTTTGAGCCATGA

Structures

Toxin

• AlphaFold DB: U2HGC0