Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2447266..2449016 Replicon chromosome
Accession NZ_CP095497
Organism Burkholderia cepacia strain BRDJ

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag MW307_RS17420 Protein ID WP_119337282.1
Coordinates 2448120..2449016 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4S5DGT0
Locus tag MW307_RS17415 Protein ID WP_027789379.1
Coordinates 2447266..2448123 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW307_RS17395 2442429..2443919 - 1491 WP_059697594.1 aldehyde dehydrogenase -
MW307_RS17400 2443992..2444819 - 828 WP_060199269.1 aspartate dehydrogenase -
MW307_RS17405 2444812..2446479 - 1668 WP_060173495.1 thiamine pyrophosphate-binding protein -
MW307_RS17410 2446472..2447269 - 798 WP_048022634.1 SDR family oxidoreductase -
MW307_RS17415 2447266..2448123 - 858 WP_027789379.1 IclR family transcriptional regulator Antitoxin
MW307_RS17420 2448120..2449016 - 897 WP_119337282.1 alpha/beta fold hydrolase Toxin
MW307_RS17425 2449035..2449562 - 528 WP_021161513.1 cupin domain-containing protein -
MW307_RS17430 2449596..2450366 - 771 WP_027789381.1 SDR family oxidoreductase -
MW307_RS17435 2450359..2451429 - 1071 WP_059697603.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
MW307_RS17440 2451484..2451795 - 312 WP_027789383.1 hypothetical protein -
MW307_RS17445 2451799..2452116 - 318 WP_027789384.1 non-heme iron oxygenase ferredoxin subunit -
MW307_RS17450 2452562..2453641 + 1080 WP_060083660.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30701.98 Da        Isoelectric Point: 8.3552

>T242057 WP_119337282.1 NZ_CP095497:c2449016-2448120 [Burkholderia cepacia]
MSVIDKRERERTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDKLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEARAWVRWNMARIVPAGYAQATHLLANADLAADLSGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDSFCRQCDQQRGLA

Download         Length: 897 bp

>T242057 NZ_OV049808:c5020978-5019656 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31511.04 Da        Isoelectric Point: 6.5068

>AT242057 WP_027789379.1 NZ_CP095497:c2448123-2447266 [Burkholderia cepacia]
MNEPLQRPEPENDKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR

Download         Length: 858 bp

>AT242057 NZ_OV049808:c5021244-5020978 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4S5DGT0

References