Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 963901..964521 Replicon chromosome
Accession NZ_CP095497
Organism Burkholderia cepacia strain BRDJ

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MW307_RS10805 Protein ID WP_162923015.1
Coordinates 964204..964521 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MW307_RS10800 Protein ID WP_119337146.1
Coordinates 963901..964200 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW307_RS10775 959033..960304 + 1272 WP_119337161.1 anthranilate 1,2-dioxygenase large subunit AndAc -
MW307_RS10780 960322..960807 + 486 WP_034196026.1 anthranilate 1,2-dioxygenase small subunit AndAd -
MW307_RS10785 960828..961154 + 327 WP_006479527.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
MW307_RS10790 961144..962364 + 1221 WP_119337147.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
MW307_RS10795 962558..963844 + 1287 WP_059684715.1 DUF445 domain-containing protein -
MW307_RS10800 963901..964200 - 300 WP_119337146.1 putative addiction module antidote protein Antitoxin
MW307_RS10805 964204..964521 - 318 WP_162923015.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MW307_RS10810 964882..966522 + 1641 WP_027790992.1 acetolactate synthase large subunit -
MW307_RS10815 966552..967985 + 1434 WP_119337144.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-100)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11793.47 Da        Isoelectric Point: 9.9729

>T242054 WP_162923015.1 NZ_CP095497:c964521-964204 [Burkholderia cepacia]
MPYSAPTFSIRTTDVFDAWFAGLRDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRGTIWVILL
GGGDTSTQQADIRAAHAMLAHLDME

Download         Length: 318 bp

>T242054 NZ_OV049808:3682851-3683267 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATTATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACCGACATCCGGGTGGCGCTGCACCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTGCCTGGACTGACACTGG
AAGACTGGGTTATTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10592.00 Da        Isoelectric Point: 6.4761

>AT242054 WP_119337146.1 NZ_CP095497:c964200-963901 [Burkholderia cepacia]
MNKISTRPWDSADHLKTEDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAPA

Download         Length: 300 bp

>AT242054 NZ_OV049808:3682624-3682854 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References