Detailed information of TA system TA242053

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 10320950..10321617
• Replicon: chromosome
• Accession: NZ_CP095481
• Organism: Amycolatopsis sp. WQ 127309

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MUY22_RS45470
• Protein ID: WP_247054161.1
• Coordinates: 10320950..10321348 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MUY22_RS45475
• Protein ID: WP_247054163.1
• Coordinates: 10321345..10321617 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUY22_RS45440 (MUY22_45440)	10316248..10317180	+	933	WP_247054149.1	ABC transporter permease subunit	-
MUY22_RS45445 (MUY22_45445)	10317242..10318003	+	762	WP_247054151.1	enoyl-CoA hydratase/isomerase family protein	-
MUY22_RS45450 (MUY22_45450)	10318000..10318503	-	504	WP_247054153.1	SRPBCC family protein	-
MUY22_RS45455 (MUY22_45455)	10318740..10320146	+	1407	WP_247054155.1	S28 family serine protease	-
MUY22_RS45460 (MUY22_45460)	10320214..10320603	+	390	WP_247054157.1	VOC family protein	-
MUY22_RS45465 (MUY22_45465)	10320606..10320953	-	348	WP_247054159.1	MmcQ/YjbR family DNA-binding protein	-
MUY22_RS45470 (MUY22_45470)	10320950..10321348	-	399	WP_247054161.1	type II toxin-antitoxin system VapC family toxin	Toxin
MUY22_RS45475 (MUY22_45475)	10321345..10321617	-	273	WP_247054163.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MUY22_RS45480 (MUY22_45480)	10321710..10323842	-	2133	WP_247064432.1	excinuclease ABC subunit UvrB	-
MUY22_RS45485 (MUY22_45485)	10323913..10324524	-	612	WP_247054165.1	carboxymuconolactone decarboxylase family protein	-
MUY22_RS45490 (MUY22_45490)	10324536..10326206	-	1671	WP_247054167.1	DUF5685 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-119)

Antitoxin

• Antitoxin VapB-like (1-77)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14381.37 Da
• Isoelectric Point: 4.7784

>T242053 WP_247054161.1 NZ_CP095481:c10321348-10320950 [Amycolatopsis sp. WQ 127309]
VIIDSSAIVAILRQEPDHERLEERLAEADSARIGAPTLVEVGIVLTTRLGARGQLVLARFLQDNNIATAPFTEEHAEVAI
EAFKQYGKGHHPAKLNMGDCYSYATAKVAREPLLCIGDDFPQTDLELVKLGS

Nucleotide

• Length: 399 bp

>T242053 NZ_OV049808:3022667-3023077 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10161.75 Da
• Isoelectric Point: 4.7605

>AT242053 WP_247054163.1 NZ_CP095481:c10321617-10321345 [Amycolatopsis sp. WQ 127309]
MAMNIKDPEAERLAAEVAALTGDTKTGAVREALRLRRDQLMARDNAEVRLKRMRRVLEEEIWPLIPPEELGKPIPKDEWE
EILGFGPGGV

Nucleotide

• Length: 273 bp

>AT242053 NZ_OV049808:3022420-3022686 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA