Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3569242..3569878 Replicon chromosome
Accession NZ_CP095476
Organism Bacillus glycinifermentans strain MGMM1

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag MW696_RS18145 Protein ID WP_003179128.1
Coordinates 3569528..3569878 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A6I7F8B4
Locus tag MW696_RS18140 Protein ID WP_026585993.1
Coordinates 3569242..3569523 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW696_RS18120 (MW696_18125) 3564403..3565884 + 1482 WP_048356046.1 PH domain-containing protein -
MW696_RS18125 (MW696_18130) 3565881..3566480 - 600 WP_247070397.1 rhomboid family intramembrane serine protease -
MW696_RS18130 (MW696_18135) 3566762..3567778 + 1017 WP_096892205.1 outer membrane lipoprotein carrier protein LolA -
MW696_RS18135 (MW696_18140) 3567973..3569133 + 1161 WP_247070398.1 alanine racemase -
MW696_RS18140 (MW696_18145) 3569242..3569523 + 282 WP_026585993.1 hypothetical protein Antitoxin
MW696_RS18145 (MW696_18150) 3569528..3569878 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
MW696_RS18150 (MW696_18155) 3569998..3570822 + 825 WP_048356048.1 STAS domain-containing protein -
MW696_RS18155 (MW696_18160) 3570825..3571190 + 366 WP_046132197.1 STAS domain-containing protein -
MW696_RS18160 (MW696_18165) 3571193..3571594 + 402 WP_048356049.1 anti-sigma regulatory factor -
MW696_RS18165 (MW696_18170) 3571605..3572612 + 1008 WP_247070399.1 PP2C family protein-serine/threonine phosphatase -
MW696_RS18170 (MW696_18175) 3572671..3572997 + 327 WP_247070400.1 anti-sigma factor antagonist -
MW696_RS18175 (MW696_18180) 3572997..3573479 + 483 WP_046132193.1 anti-sigma B factor RsbW -
MW696_RS18180 (MW696_18185) 3573445..3574236 + 792 WP_247073287.1 RNA polymerase sigma factor SigB -
MW696_RS18185 (MW696_18190) 3574233..3574832 + 600 WP_247070401.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T242052 WP_003179128.1 NZ_CP095476:3569528-3569878 [Bacillus glycinifermentans]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T242052 NZ_OV049808:2545194-2545541 [Klebsiella pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10667.07 Da        Isoelectric Point: 4.6920

>AT242052 WP_026585993.1 NZ_CP095476:3569242-3569523 [Bacillus glycinifermentans]
MSESSATTEIMIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT242052 NZ_OV049808:2545541-2545840 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB A0A6I7F8B4

References