Detailed information of TA system TA242050

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2523201..2523847
• Replicon: chromosome
• Accession: NZ_CP095475
• Organism: Pseudoxanthomonas winnipegensis strain ZSY-33

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MWN52_RS11285
• Protein ID: WP_286574711.1
• Coordinates: 2523201..2523614 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MWN52_RS11290
• Protein ID: WP_286574712.1
• Coordinates: 2523611..2523847 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MWN52_RS11265 (MWN52_11290)	2518812..2519252	-	441	WP_131659783.1	Hsp20/alpha crystallin family protein	-
MWN52_RS11270 (MWN52_11295)	2519431..2519913	+	483	WP_286574709.1	peroxiredoxin	-
MWN52_RS11275 (MWN52_11300)	2519951..2520523	+	573	WP_130517870.1	ferritin-like domain-containing protein	-
MWN52_RS11280 (MWN52_11305)	2520711..2523071	-	2361	WP_286574710.1	penicillin-binding protein 1C	-
MWN52_RS11285 (MWN52_11310)	2523201..2523614	-	414	WP_286574711.1	type II toxin-antitoxin system VapC family toxin	Toxin
MWN52_RS11290 (MWN52_11315)	2523611..2523847	-	237	WP_286574712.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MWN52_RS11295 (MWN52_11320)	2524065..2524568	-	504	WP_286574713.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-126)

Antitoxin

• SpoVT-AbrB domain (8-44)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15013.26 Da
• Isoelectric Point: 7.1651

>T242050 WP_286574711.1 NZ_CP095475:c2523614-2523201 [Pseudoxanthomonas winnipegensis]
MSRVLYLLDTNICIYIINRRPPGVFEHFAGLQIGQIAISSITGAELDYGVAKSGSQRNRQALDKFLAPLDVLSFDEAAMR
RYGALRSGLERQGTPIGAMDQLIAAHALALDAVLVSNNLREFERVPGLRLENWVSAG

Nucleotide

• Length: 414 bp

>T242050 NZ_OV049808:c2099375-2098992 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9054.37 Da
• Isoelectric Point: 6.3168

>AT242050 WP_286574712.1 NZ_CP095475:c2523847-2523611 [Pseudoxanthomonas winnipegensis]
MTTTAKLFQSGRSQAVRLPKALRFEGDQVIARRFGNGVLLLPVEAPWQLMREALEEFEPGFALQRDQPEQQVREDWLR

Nucleotide

• Length: 237 bp

>AT242050 NZ_OV049808:c2099617-2099375 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA