Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1977192..1977748 Replicon chromosome
Accession NZ_CP095475
Organism Pseudoxanthomonas winnipegensis strain ZSY-33

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag MWN52_RS08795 Protein ID WP_286577505.1
Coordinates 1977192..1977482 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MWN52_RS08800 Protein ID WP_286577507.1
Coordinates 1977470..1977748 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWN52_RS08775 (MWN52_08800) 1972749..1973246 - 498 WP_286577500.1 GNAT family N-acetyltransferase -
MWN52_RS08780 (MWN52_08805) 1973246..1974598 - 1353 WP_286577501.1 nucleobase:cation symporter-2 family protein -
MWN52_RS08785 (MWN52_08810) 1974779..1975579 - 801 WP_286577502.1 hypothetical protein -
MWN52_RS08790 (MWN52_08815) 1975589..1977013 - 1425 WP_286577504.1 hypothetical protein -
MWN52_RS08795 (MWN52_08820) 1977192..1977482 - 291 WP_286577505.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MWN52_RS08800 (MWN52_08825) 1977470..1977748 - 279 WP_286577507.1 CopG family ribbon-helix-helix protein Antitoxin
MWN52_RS08805 (MWN52_08830) 1977857..1978819 - 963 WP_286577508.1 LysR family transcriptional regulator -
MWN52_RS08810 (MWN52_08835) 1978941..1980002 + 1062 WP_286577509.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
MWN52_RS08815 (MWN52_08840) 1980002..1980967 + 966 WP_286577510.1 PDR/VanB family oxidoreductase -
MWN52_RS08820 (MWN52_08845) 1980973..1982355 + 1383 WP_286577511.1 AtzE family amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11081.80 Da        Isoelectric Point: 10.0309

>T242049 WP_286577505.1 NZ_CP095475:c1977482-1977192 [Pseudoxanthomonas winnipegensis]
MPHLSWAPAAVSDIQRLYRFLLPKNADAARRAIKAIREGVKILARQPRIGRPIEDLPTEFRDWPIDFGDDGYVVRYRIEN
EVVTILAVRHQKEAGF

Download         Length: 291 bp

>T242049 NZ_OV049808:c1608656-1608372 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10713.97 Da        Isoelectric Point: 5.6072

>AT242049 WP_286577507.1 NZ_CP095475:c1977748-1977470 [Pseudoxanthomonas winnipegensis]
MASPTSLKLDQAMKERIQHLADTRRRSPHWIMREAIAQYVEREEQREAFRQDTLRAWEEFQRTGLHLTGAEADAWLARLE
AGEDAEPPACHT

Download         Length: 279 bp

>AT242049 NZ_OV049808:c1608888-1608646 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References