Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1458945..1459431 Replicon chromosome
Accession NZ_CP095463
Organism Streptococcus suis strain TJS56

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag MU520_RS07135 Protein ID WP_011922754.1
Coordinates 1458945..1459214 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag MU520_RS07140 Protein ID WP_002938604.1
Coordinates 1459204..1459431 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU520_RS07110 1453998..1454915 - 918 WP_002937252.1 DNA-binding protein WhiA -
MU520_RS07115 1454912..1455886 - 975 WP_002937257.1 YvcK family protein -
MU520_RS07120 1455883..1456770 - 888 WP_011922160.1 RNase adapter RapZ -
MU520_RS07125 1456792..1457169 - 378 WP_002937263.1 RidA family protein -
MU520_RS07130 1457220..1458539 - 1320 Protein_1411 MATE family efflux transporter -
MU520_RS07135 1458945..1459214 - 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MU520_RS07140 1459204..1459431 - 228 WP_002938604.1 DUF6290 family protein Antitoxin
MU520_RS07145 1459703..1461049 - 1347 WP_011922752.1 asparagine--tRNA ligase -
MU520_RS07150 1461064..1462245 - 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
MU520_RS07155 1462242..1462739 - 498 WP_011922751.1 DUF5590 domain-containing protein -
MU520_RS07165 1463939..1464388 + 450 WP_009909619.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T242048 WP_011922754.1 NZ_CP095463:c1459214-1458945 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T242048 NZ_OV049808:c1504028-1503495 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT242048 WP_002938604.1 NZ_CP095463:c1459431-1459204 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT242048 NZ_OV049808:c1504305-1504039 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References