Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1200095..1200587 Replicon chromosome
Accession NZ_CP095463
Organism Streptococcus suis strain TJS56

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag MU520_RS05910 Protein ID WP_011922404.1
Coordinates 1200330..1200587 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag MU520_RS05905 Protein ID WP_012775104.1
Coordinates 1200095..1200346 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU520_RS05885 1195662..1196408 + 747 WP_011922411.1 ABC transporter permease -
MU520_RS05890 1196410..1197144 + 735 WP_011922410.1 ABC transporter permease -
MU520_RS05895 1197280..1198032 + 753 WP_011922409.1 ABC transporter ATP-binding protein -
MU520_RS05900 1198033..1200003 + 1971 WP_012775105.1 FtsX-like permease family protein -
MU520_RS05905 1200095..1200346 + 252 WP_012775104.1 DUF6290 family protein Antitoxin
MU520_RS05910 1200330..1200587 + 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MU520_RS05915 1200626..1201291 + 666 WP_012775103.1 response regulator transcription factor -
MU520_RS05920 1201288..1202229 + 942 WP_012775102.1 sensor histidine kinase -
MU520_RS05925 1202305..1203813 + 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
MU520_RS05930 1203883..1204953 - 1071 WP_012775101.1 tyrosine recombinase XerS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T242047 WP_011922404.1 NZ_CP095463:1200330-1200587 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T242047 NZ_OV049808:871284-871502 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT242047 WP_012775104.1 NZ_CP095463:1200095-1200346 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT242047 NZ_OV049808:870883-871257 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References