Detailed information of TA system TA242043

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/MazF(toxin)
• Location: 2655472..2656115
• Replicon: chromosome
• Accession: NZ_CP095462
• Organism: Bacillus sp. JY-23

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: -
• Locus tag: MUG87_RS13700
• Protein ID: WP_124565881.1
• Coordinates: 2655765..2656115 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: MUG87_RS13695
• Protein ID: WP_124565880.1
• Coordinates: 2655472..2655759 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUG87_RS13675 (MUG87_13675)	2651349..2652311	+	963	WP_247082859.1	UV DNA damage repair endonuclease UvsE	-
MUG87_RS13680 (MUG87_13680)	2652379..2652735	+	357	WP_124565878.1	holo-ACP synthase	-
MUG87_RS13685 (MUG87_13685)	2652865..2653833	+	969	WP_247087692.1	outer membrane lipoprotein carrier protein LolA	-
MUG87_RS13690 (MUG87_13690)	2654168..2655331	+	1164	WP_247082861.1	alanine racemase	-
MUG87_RS13695 (MUG87_13695)	2655472..2655759	+	288	WP_124565880.1	antitoxin endoai	Antitoxin
MUG87_RS13700 (MUG87_13700)	2655765..2656115	+	351	WP_124565881.1	type II toxin-antitoxin system endoribonuclease NdoA	Toxin
MUG87_RS13705 (MUG87_13705)	2656172..2658328	+	2157	WP_247082862.1	Tex family protein	-
MUG87_RS13710 (MUG87_13710)	2658337..2658456	-	120	WP_247082863.1	cortex morphogenetic protein CmpA	-
MUG87_RS13715 (MUG87_13715)	2658540..2658992	+	453	WP_247082864.1	SprT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12970.01 Da
• Isoelectric Point: 6.2250

>T242043 WP_124565881.1 NZ_CP095462:2655765-2656115 [Bacillus sp. JY-23]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDGMMHRVDEALQISLGLIDF

Nucleotide

• Length: 351 bp

>T242043 NZ_OV040719:628752-629030 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGTGTTCAACAGGCTTATACAGA
CATTGGCGCAGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAATATGAATGAAGATATGGCGA
ATCTCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCTGTACGAGATATTCGCGCTTTTCGTATT
GAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10835.35 Da
• Isoelectric Point: 6.7120

>AT242043 WP_124565880.1 NZ_CP095462:2655472-2655759 [Bacillus sp. JY-23]
VSESSVTTEIVIRLPKQIISELDGIVQRENCNRNELICEAAKMFLRQHKTKKKYQHDSIRRGYIEMGEINLNIASESFLA
EYEAAHTVERLVSGG

Nucleotide

• Length: 288 bp

>AT242043 NZ_OV040719:628552-628743 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTAT
CTCACCTGCTTGAAGATCCCGAAGCTGAATAA