Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4604102..4604900 Replicon chromosome
Accession NZ_CP095448
Organism Escherichia coli strain LS45

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag MWN28_RS22430 Protein ID WP_000854735.1
Coordinates 4604523..4604900 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag MWN28_RS22425 Protein ID WP_001285415.1
Coordinates 4604102..4604476 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWN28_RS22390 (4600033) 4600033..4600713 + 681 WP_001282919.1 WYL domain-containing protein -
MWN28_RS22395 (4600861) 4600861..4601538 + 678 WP_001097302.1 hypothetical protein -
MWN28_RS22400 (4601544) 4601544..4601777 + 234 WP_072645932.1 DUF905 family protein -
MWN28_RS22405 (4601867) 4601867..4602685 + 819 WP_001175148.1 DUF932 domain-containing protein -
MWN28_RS22410 (4602767) 4602767..4603246 + 480 WP_000844100.1 antirestriction protein -
MWN28_RS22415 (4603262) 4603262..4603738 + 477 WP_001366855.1 RadC family protein -
MWN28_RS22420 (4603801) 4603801..4604022 + 222 WP_000692309.1 DUF987 domain-containing protein -
MWN28_RS22425 (4604102) 4604102..4604476 + 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MWN28_RS22430 (4604523) 4604523..4604900 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
MWN28_RS22435 (4604897) 4604897..4605385 + 489 WP_000761676.1 DUF5983 family protein -
MWN28_RS22440 (4605397) 4605397..4605594 + 198 WP_000839291.1 DUF957 domain-containing protein -
MWN28_RS22445 (4605679) 4605679..4606545 + 867 WP_001280433.1 DUF4942 domain-containing protein -
MWN28_RS22450 (4606617) 4606617..4606880 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
MWN28_RS22455 (4606877) 4606877..4607203 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
MWN28_RS22460 (4608086) 4608086..4609624 + 1539 WP_001187186.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4547940..4617437 69497


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T242035 WP_000854735.1 NZ_CP095448:4604523-4604900 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T242035 NZ_OV040584:46303-46701 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCTGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT242035 WP_001285415.1 NZ_CP095448:4604102-4604476 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT242035 NZ_OV040584:46070-46303 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References