Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 875388..876223 | Replicon | chromosome |
Accession | NZ_CP095448 | ||
Organism | Escherichia coli strain LS45 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | S1EZ92 |
Locus tag | MWN28_RS04145 | Protein ID | WP_000854726.1 |
Coordinates | 875388..875765 (-) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | - |
Locus tag | MWN28_RS04150 | Protein ID | WP_049043351.1 |
Coordinates | 875855..876223 (-) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MWN28_RS04115 (870502) | 870502..871650 | - | 1149 | WP_000905926.1 | capsule polysaccharide export inner-membrane protein KpsE | - |
MWN28_RS04120 (871722) | 871722..872705 | - | 984 | WP_001298261.1 | KpsF/GutQ family sugar-phosphate isomerase | - |
MWN28_RS04125 (873516) | 873516..873686 | - | 171 | Protein_811 | IS110 family transposase | - |
MWN28_RS04130 (874028) | 874028..874597 | - | 570 | WP_016231187.1 | DUF4942 domain-containing protein | - |
MWN28_RS04135 (874694) | 874694..874891 | - | 198 | WP_016231186.1 | DUF957 domain-containing protein | - |
MWN28_RS04140 (874903) | 874903..875391 | - | 489 | WP_072754450.1 | DUF5983 family protein | - |
MWN28_RS04145 (875388) | 875388..875765 | - | 378 | WP_000854726.1 | TA system toxin CbtA family protein | Toxin |
MWN28_RS04150 (875855) | 875855..876223 | - | 369 | WP_049043351.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
MWN28_RS04155 (876273) | 876273..876917 | - | 645 | Protein_817 | antitoxin of toxin-antitoxin stability system | - |
MWN28_RS04160 (876932) | 876932..877153 | - | 222 | WP_000692346.1 | DUF987 domain-containing protein | - |
MWN28_RS04165 (877216) | 877216..877692 | - | 477 | WP_001186774.1 | RadC family protein | - |
MWN28_RS04170 (877708) | 877708..878193 | - | 486 | WP_021547706.1 | antirestriction protein | - |
MWN28_RS04175 (878285) | 878285..879103 | - | 819 | WP_021547707.1 | DUF932 domain-containing protein | - |
MWN28_RS04180 (879193) | 879193..879426 | - | 234 | WP_001278282.1 | DUF905 family protein | - |
MWN28_RS04185 (879432) | 879432..880109 | - | 678 | WP_001097567.1 | hypothetical protein | - |
MWN28_RS04190 (880260) | 880260..880940 | - | 681 | WP_001282912.1 | WYL domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14164.10 Da Isoelectric Point: 7.8045
>T242008 WP_000854726.1 NZ_CP095448:c875765-875388 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T242008 NZ_OU943337:1974593-1974695 [Salmonella enterica subsp. enterica serovar Typhi]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 123 a.a. Molecular weight: 13550.23 Da Isoelectric Point: 5.8786
>AT242008 WP_049043351.1 NZ_CP095448:c876223-875855 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT242008 NZ_OU943337:c1974697-1974554 [Salmonella enterica subsp. enterica serovar Typhi]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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