Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 875388..876223 Replicon chromosome
Accession NZ_CP095448
Organism Escherichia coli strain LS45

Toxin (Protein)


Gene name yeeV Uniprot ID S1EZ92
Locus tag MWN28_RS04145 Protein ID WP_000854726.1
Coordinates 875388..875765 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag MWN28_RS04150 Protein ID WP_049043351.1
Coordinates 875855..876223 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWN28_RS04115 (870502) 870502..871650 - 1149 WP_000905926.1 capsule polysaccharide export inner-membrane protein KpsE -
MWN28_RS04120 (871722) 871722..872705 - 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -
MWN28_RS04125 (873516) 873516..873686 - 171 Protein_811 IS110 family transposase -
MWN28_RS04130 (874028) 874028..874597 - 570 WP_016231187.1 DUF4942 domain-containing protein -
MWN28_RS04135 (874694) 874694..874891 - 198 WP_016231186.1 DUF957 domain-containing protein -
MWN28_RS04140 (874903) 874903..875391 - 489 WP_072754450.1 DUF5983 family protein -
MWN28_RS04145 (875388) 875388..875765 - 378 WP_000854726.1 TA system toxin CbtA family protein Toxin
MWN28_RS04150 (875855) 875855..876223 - 369 WP_049043351.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MWN28_RS04155 (876273) 876273..876917 - 645 Protein_817 antitoxin of toxin-antitoxin stability system -
MWN28_RS04160 (876932) 876932..877153 - 222 WP_000692346.1 DUF987 domain-containing protein -
MWN28_RS04165 (877216) 877216..877692 - 477 WP_001186774.1 RadC family protein -
MWN28_RS04170 (877708) 877708..878193 - 486 WP_021547706.1 antirestriction protein -
MWN28_RS04175 (878285) 878285..879103 - 819 WP_021547707.1 DUF932 domain-containing protein -
MWN28_RS04180 (879193) 879193..879426 - 234 WP_001278282.1 DUF905 family protein -
MWN28_RS04185 (879432) 879432..880109 - 678 WP_001097567.1 hypothetical protein -
MWN28_RS04190 (880260) 880260..880940 - 681 WP_001282912.1 WYL domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14164.10 Da        Isoelectric Point: 7.8045

>T242008 WP_000854726.1 NZ_CP095448:c875765-875388 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T242008 NZ_OU943337:1974593-1974695 [Salmonella enterica subsp. enterica serovar Typhi]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13550.23 Da        Isoelectric Point: 5.8786

>AT242008 WP_049043351.1 NZ_CP095448:c876223-875855 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT242008 NZ_OU943337:c1974697-1974554 [Salmonella enterica subsp. enterica serovar Typhi]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1EZ92


Antitoxin

Source ID Structure

References