Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pmenTA/darT(toxin) |
| Location | 4283401..4285130 | Replicon | chromosome |
| Accession | NZ_CP095443 | ||
| Organism | Providencia stuartii strain CMC-4104 | ||
Toxin (Protein)
| Gene name | pmenT | Uniprot ID | - |
| Locus tag | MWH14_RS19950 | Protein ID | WP_154623506.1 |
| Coordinates | 4283401..4284045 (+) | Length | 215 a.a. |
Antitoxin (Protein)
| Gene name | pmenA | Uniprot ID | - |
| Locus tag | MWH14_RS19955 | Protein ID | WP_154623505.1 |
| Coordinates | 4284057..4285130 (+) | Length | 358 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MWH14_RS19935 (MWH14_19935) | 4280987..4281817 | + | 831 | WP_154624783.1 | formate dehydrogenase accessory sulfurtransferase FdhD | - |
| MWH14_RS19940 (MWH14_19940) | 4281821..4282600 | - | 780 | WP_249999547.1 | transferase | - |
| MWH14_RS19945 (MWH14_19945) | 4282832..4283401 | + | 570 | WP_154623507.1 | DarT ssDNA thymidine ADP-ribosyltransferase family protein | - |
| MWH14_RS19950 (MWH14_19950) | 4283401..4284045 | + | 645 | WP_154623506.1 | DUF4433 domain-containing protein | Toxin |
| MWH14_RS19955 (MWH14_19955) | 4284057..4285130 | + | 1074 | WP_154623505.1 | macro domain-containing protein | Antitoxin |
| MWH14_RS19960 (MWH14_19960) | 4285407..4286441 | + | 1035 | WP_001143643.1 | DUF4365 domain-containing protein | - |
| MWH14_RS19965 (MWH14_19965) | 4286554..4286646 | + | 93 | Protein_3810 | hypothetical protein | - |
| MWH14_RS19970 (MWH14_19970) | 4286786..4287550 | - | 765 | WP_001389365.1 | IS6-like element IS6100 family transposase | - |
| MWH14_RS19980 (MWH14_19980) | 4288057..4288557 | - | 501 | WP_000376623.1 | GNAT family N-acetyltransferase | - |
| MWH14_RS19985 (MWH14_19985) | 4288685..4289524 | - | 840 | WP_000259031.1 | sulfonamide-resistant dihydropteroate synthase Sul1 | - |
| MWH14_RS19990 (MWH14_19990) | 4289518..4289865 | - | 348 | WP_000679427.1 | quaternary ammonium compound efflux SMR transporter QacE delta 1 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 215 a.a. Molecular weight: 25047.66 Da Isoelectric Point: 6.9106
>T242006 WP_154623506.1 NZ_CP095443:4283401-4284045 [Providencia stuartii]
MAYMNLNPEKALIWRITHRQNIPWLFANGLYAGNSEHYSPNWVTIGNTDLINRRNQRHVPIQPNGVLNDYVPFYFTPFSP
MMYNIYTGRGGVRKVPNDDIIILVSSMYKIAALKIPFVFTDRHAYPVTSQFYNQLTDLAEIDWALLQQRNFHRDPDDPEK
VERYQAEALIYKHVPMEALLGAVCYTKETQLELQAKASQLEIHLDIHCIPNWYF
MAYMNLNPEKALIWRITHRQNIPWLFANGLYAGNSEHYSPNWVTIGNTDLINRRNQRHVPIQPNGVLNDYVPFYFTPFSP
MMYNIYTGRGGVRKVPNDDIIILVSSMYKIAALKIPFVFTDRHAYPVTSQFYNQLTDLAEIDWALLQQRNFHRDPDDPEK
VERYQAEALIYKHVPMEALLGAVCYTKETQLELQAKASQLEIHLDIHCIPNWYF
Download Length: 645 bp
>T242006 NZ_OU943337:822074-822472 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCTGAAATTCATGCTTGATACCAATACTTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCACCGG
AGCGTAATTTTGCAGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTACCGAACTGGCCCGCAAGGGAACACCTGTCGGGTCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA
ATGCTGAAATTCATGCTTGATACCAATACTTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCACCGG
AGCGTAATTTTGCAGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTACCGAACTGGCCCGCAAGGGAACACCTGTCGGGTCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA
Antitoxin
Download Length: 358 a.a. Molecular weight: 40807.28 Da Isoelectric Point: 7.8198
>AT242006 WP_154623505.1 NZ_CP095443:4284057-4285130 [Providencia stuartii]
MIEFTQGNLLEADVEALVNTVNTVGVMGKGIALMFKERFPANMAAYAKACKTHEVQTGKMFVTETGELMGPRWIVNFPTK
QHWRAKSQIQWIIDGLLDLRNFIEENHVKSIAIPPLGAGNGGLNWDDVKPHIVEILGDIQNVKIIVYEPIAKYQNVAKPK
GVEKLTPARALIAELIRRYWVMGMDCSLLEIQKLAWFLERTIEAEGLRNPLNLRFEARNYGPYADKLRHLLNGLDGSYLK
SEKRISDCSPLDVIWFNDDKRATIELYLKTEAKDYLSALEKTTKLIDGFESPFGIELLSTVDWLLYKKQSSPNIESLLEG
MRQWPAGDRWAQRKLRLFDSNKLELALNHLKQIPFYS
MIEFTQGNLLEADVEALVNTVNTVGVMGKGIALMFKERFPANMAAYAKACKTHEVQTGKMFVTETGELMGPRWIVNFPTK
QHWRAKSQIQWIIDGLLDLRNFIEENHVKSIAIPPLGAGNGGLNWDDVKPHIVEILGDIQNVKIIVYEPIAKYQNVAKPK
GVEKLTPARALIAELIRRYWVMGMDCSLLEIQKLAWFLERTIEAEGLRNPLNLRFEARNYGPYADKLRHLLNGLDGSYLK
SEKRISDCSPLDVIWFNDDKRATIELYLKTEAKDYLSALEKTTKLIDGFESPFGIELLSTVDWLLYKKQSSPNIESLLEG
MRQWPAGDRWAQRKLRLFDSNKLELALNHLKQIPFYS
Download Length: 1074 bp
>AT242006 NZ_OU943337:821847-822074 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGCACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGCACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|