Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1525861..1526518 Replicon chromosome
Accession NZ_CP095443
Organism Providencia stuartii strain CMC-4104

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag MWH14_RS06980 Protein ID WP_163860914.1
Coordinates 1526108..1526518 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag MWH14_RS06975 Protein ID WP_154624313.1
Coordinates 1525861..1526127 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWH14_RS06960 (MWH14_06960) 1521013..1523889 + 2877 WP_163860913.1 aminomethyl-transferring glycine dehydrogenase -
MWH14_RS06965 (MWH14_06965) 1523986..1524606 - 621 WP_154624315.1 HD domain-containing protein -
MWH14_RS06970 (MWH14_06970) 1524618..1525607 - 990 WP_154624314.1 tRNA-modifying protein YgfZ -
MWH14_RS06975 (MWH14_06975) 1525861..1526127 + 267 WP_154624313.1 FAD assembly factor SdhE Antitoxin
MWH14_RS06980 (MWH14_06980) 1526108..1526518 + 411 WP_163860914.1 protein YgfX Toxin
MWH14_RS06985 (MWH14_06985) 1526563..1527081 - 519 WP_154624312.1 flavodoxin FldB -
MWH14_RS06990 (MWH14_06990) 1527166..1528089 + 924 WP_247047071.1 site-specific tyrosine recombinase XerD -
MWH14_RS06995 (MWH14_06995) 1528109..1528810 + 702 WP_154624311.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MWH14_RS07000 (MWH14_07000) 1528820..1530553 + 1734 WP_247047060.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15375.24 Da        Isoelectric Point: 10.8779

>T242005 WP_163860914.1 NZ_CP095443:1526108-1526518 [Providencia stuartii]
VVLWKSNLSISWKTQLFSTCAHGLVGFILLVAPWAPGNSMVWLPLLAIVIASWAKSQKSISKIKGTAVLVNGNKVQWKKN
EWNIIKQPWCSRVGILLTLSALQGKQQKIRLWIAKDALSEESWRNLNQLLLQYPDI

Download         Length: 411 bp

>T242005 NZ_OU943337:805351-805752 [Salmonella enterica subsp. enterica serovar Typhi]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCCTTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGACAG
GACTGGACGCTCTTGCGTCCTCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
AG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10578.07 Da        Isoelectric Point: 4.7132

>AT242005 WP_154624313.1 NZ_CP095443:1525861-1526127 [Providencia stuartii]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDSLSDKDKQTFVRLLECADPDLFNWLMNHGRPDDEELFGMVKLIQERN
KNRGPVEI

Download         Length: 267 bp

>AT242005 NZ_OU943337:805104-805370 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References