Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-parE/ParE-RHH |
| Location | 17026..17606 | Replicon | plasmid pIM007_4 |
| Accession | NZ_CP095432 | ||
| Organism | Klebsiella pneumoniae strain IM007 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A8J3DTL7 |
| Locus tag | MWR71_RS30280 | Protein ID | WP_071177730.1 |
| Coordinates | 17026..17340 (-) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A2X1PRM1 |
| Locus tag | MWR71_RS30285 | Protein ID | WP_000093040.1 |
| Coordinates | 17328..17606 (-) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MWR71_RS30255 (MWR71_30210) | 12970..14934 | + | 1965 | WP_071177727.1 | TraM recognition domain-containing protein | - |
| MWR71_RS30260 (MWR71_30215) | 14934..15665 | + | 732 | WP_071177728.1 | MobC family replication-relaxation protein | - |
| MWR71_RS30265 (MWR71_30220) | 15672..16202 | + | 531 | WP_071177729.1 | hypothetical protein | - |
| MWR71_RS30270 (MWR71_30225) | 16229..16408 | - | 180 | WP_000165970.1 | Rop family plasmid primer RNA-binding protein | - |
| MWR71_RS30275 (MWR71_30230) | 16434..16862 | - | 429 | WP_001140599.1 | hypothetical protein | - |
| MWR71_RS30280 (MWR71_30235) | 17026..17340 | - | 315 | WP_071177730.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MWR71_RS30285 (MWR71_30240) | 17328..17606 | - | 279 | WP_000093040.1 | CopG family ribbon-helix-helix protein | Antitoxin |
| MWR71_RS30290 (MWR71_30245) | 17781..18146 | - | 366 | WP_072354022.1 | TonB family protein | - |
| MWR71_RS30295 (MWR71_30250) | 18143..18514 | - | 372 | WP_001237044.1 | cell envelope integrity protein TolA | - |
| MWR71_RS30300 (MWR71_30255) | 18788..19033 | - | 246 | WP_032440458.1 | hypothetical protein | - |
| MWR71_RS30305 (MWR71_30260) | 19678..21167 | + | 1490 | Protein_25 | group II intron reverse transcriptase/maturase | - |
| MWR71_RS30310 (MWR71_30265) | 21160..21903 | + | 744 | WP_271237397.1 | colicin-like bacteriocin tRNase domain-containing protein | - |
| MWR71_RS30315 (MWR71_30270) | 21995..22138 | + | 144 | Protein_27 | colicin E3/pyocin S6 family cytotoxin | - |
| MWR71_RS30320 (MWR71_30275) | 22148..22404 | + | 257 | Protein_28 | colicin E3-like toxin immunity protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..27281 | 27281 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11805.73 Da Isoelectric Point: 9.8324
>T242003 WP_071177730.1 NZ_CP095432:c17340-17026 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL
Download Length: 315 bp
>T242003 NZ_OU943336:4519948-4520259 [Salmonella enterica subsp. enterica serovar Typhi]
GTGCATGTTATCAGCCGAAAACTGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCGCTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA
GTGCATGTTATCAGCCGAAAACTGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCGCTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10709.73 Da Isoelectric Point: 4.7561
>AT242003 WP_000093040.1 NZ_CP095432:c17606-17328 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR
Download Length: 279 bp
>AT242003 NZ_OU943336:4520256-4520702 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|