Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 193065..193735 | Replicon | plasmid pIM007_vir |
| Accession | NZ_CP095429 | ||
| Organism | Klebsiella pneumoniae strain IM007 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | Q6U619 |
| Locus tag | MWR71_RS28715 | Protein ID | WP_004213072.1 |
| Coordinates | 193292..193735 (+) | Length | 148 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | Q6U620 |
| Locus tag | MWR71_RS28710 | Protein ID | WP_004213073.1 |
| Coordinates | 193065..193295 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MWR71_RS28685 (MWR71_28635) | 189288..190187 | - | 900 | WP_004225022.1 | nucleotide-binding protein | - |
| MWR71_RS28690 (MWR71_28640) | 190177..190467 | - | 291 | WP_004213078.1 | hypothetical protein | - |
| MWR71_RS28695 (MWR71_28645) | 190819..191025 | + | 207 | WP_004213077.1 | hypothetical protein | - |
| MWR71_RS28700 (MWR71_28650) | 191015..191308 | - | 294 | WP_004213076.1 | hypothetical protein | - |
| MWR71_RS28705 (MWR71_28655) | 191324..192457 | - | 1134 | WP_004213075.1 | DUF3800 domain-containing protein | - |
| MWR71_RS28710 (MWR71_28660) | 193065..193295 | + | 231 | WP_004213073.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| MWR71_RS28715 (MWR71_28665) | 193292..193735 | + | 444 | WP_004213072.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| MWR71_RS28720 (MWR71_28670) | 193884..194135 | + | 252 | WP_186987481.1 | hypothetical protein | - |
| MWR71_RS28725 (MWR71_28675) | 194158..194462 | - | 305 | Protein_207 | transposase | - |
| MWR71_RS28730 (MWR71_28680) | 194600..195580 | + | 981 | WP_000019473.1 | IS5-like element ISKpn26 family transposase | - |
| MWR71_RS28735 (MWR71_28685) | 195744..196304 | + | 561 | WP_004213927.1 | TetR/AcrR family transcriptional regulator | - |
| MWR71_RS28740 (MWR71_28690) | 196342..196770 | + | 429 | WP_004902152.1 | DUF417 family protein | - |
| MWR71_RS28745 (MWR71_28695) | 196854..197129 | + | 276 | WP_004213932.1 | carboxymuconolactone decarboxylase family protein | - |
| MWR71_RS28750 (MWR71_28700) | 197192..197683 | + | 492 | WP_011251327.1 | DM13 domain-containing protein | - |
| MWR71_RS28755 (MWR71_28705) | 197732..198652 | + | 921 | WP_004213934.1 | DUF1471 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | iutA / iroD / iroC / iroB / rmpA2 / iucA / iucB / iucC / iucD / iutA / iroD / iroC | 1..228102 | 228102 | |
| - | flank | IS/Tn | - | - | 194600..195580 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T241997 WP_004213072.1 NZ_CP095429:193292-193735 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
Download Length: 444 bp
>T241997 NZ_OU943336:3342256-3342474 [Salmonella enterica subsp. enterica serovar Typhi]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8677.73 Da Isoelectric Point: 4.4563
>AT241997 WP_004213073.1 NZ_CP095429:193065-193295 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT241997 NZ_OU943336:3341854-3342228 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|