Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 4813384..4814038 | Replicon | chromosome |
Accession | NZ_CP095428 | ||
Organism | Klebsiella pneumoniae strain IM007 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | R4YHX2 |
Locus tag | MWR71_RS23750 | Protein ID | WP_004144731.1 |
Coordinates | 4813631..4814038 (+) | Length | 136 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | W8UQ37 |
Locus tag | MWR71_RS23745 | Protein ID | WP_002916312.1 |
Coordinates | 4813384..4813650 (+) | Length | 89 a.a. |
Genomic Context
Location: 4810870..4811181 (312 bp)
Type: Others
Protein ID: WP_002916319.1
Type: Others
Protein ID: WP_002916319.1
Location: 4811345..4812004 (660 bp)
Type: Others
Protein ID: WP_002916317.1
Type: Others
Protein ID: WP_002916317.1
Location: 4813384..4813650 (267 bp)
Type: Antitoxin
Protein ID: WP_002916312.1
Type: Antitoxin
Protein ID: WP_002916312.1
Location: 4813631..4814038 (408 bp)
Type: Toxin
Protein ID: WP_004144731.1
Type: Toxin
Protein ID: WP_004144731.1
Location: 4814667..4815563 (897 bp)
Type: Others
Protein ID: WP_004144729.1
Type: Others
Protein ID: WP_004144729.1
Location: 4815586..4816299 (714 bp)
Type: Others
Protein ID: WP_002916301.1
Type: Others
Protein ID: WP_002916301.1
Location: 4816305..4818038 (1734 bp)
Type: Others
Protein ID: WP_004151783.1
Type: Others
Protein ID: WP_004151783.1
Location: 4808540..4809973 (1434 bp)
Type: Others
Protein ID: WP_002916322.1
Type: Others
Protein ID: WP_002916322.1
Location: 4810092..4810820 (729 bp)
Type: Others
Protein ID: WP_002916321.1
Type: Others
Protein ID: WP_002916321.1
Location: 4812155..4813138 (984 bp)
Type: Others
Protein ID: WP_002916313.1
Type: Others
Protein ID: WP_002916313.1
Location: 4814045..4814566 (522 bp)
Type: Others
Protein ID: WP_002916308.1
Type: Others
Protein ID: WP_002916308.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MWR71_RS23720 (MWR71_23690) | 4808540..4809973 | - | 1434 | WP_002916322.1 | 6-phospho-beta-glucosidase BglA | - |
MWR71_RS23725 (MWR71_23695) | 4810092..4810820 | - | 729 | WP_002916321.1 | MurR/RpiR family transcriptional regulator | - |
MWR71_RS23730 (MWR71_23700) | 4810870..4811181 | + | 312 | WP_002916319.1 | N(4)-acetylcytidine aminohydrolase | - |
MWR71_RS23735 (MWR71_23705) | 4811345..4812004 | + | 660 | WP_002916317.1 | hemolysin III family protein | - |
MWR71_RS23740 (MWR71_23710) | 4812155..4813138 | - | 984 | WP_002916313.1 | tRNA-modifying protein YgfZ | - |
MWR71_RS23745 (MWR71_23715) | 4813384..4813650 | + | 267 | WP_002916312.1 | FAD assembly factor SdhE | Antitoxin |
MWR71_RS23750 (MWR71_23720) | 4813631..4814038 | + | 408 | WP_004144731.1 | protein YgfX | Toxin |
MWR71_RS23755 (MWR71_23725) | 4814045..4814566 | - | 522 | WP_002916308.1 | flavodoxin FldB | - |
MWR71_RS23760 (MWR71_23730) | 4814667..4815563 | + | 897 | WP_004144729.1 | site-specific tyrosine recombinase XerD | - |
MWR71_RS23765 (MWR71_23735) | 4815586..4816299 | + | 714 | WP_002916301.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
MWR71_RS23770 (MWR71_23740) | 4816305..4818038 | + | 1734 | WP_004151783.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 15936.69 Da Isoelectric Point: 11.4778
>T241994 WP_004144731.1 NZ_CP095428:4813631-4814038 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
Download Length: 408 bp
>T241994 NZ_OU943336:822074-822472 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCTGAAATTCATGCTTGATACCAATACTTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCACCGG
AGCGTAATTTTGCAGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTACCGAACTGGCCCGCAAGGGAACACCTGTCGGGTCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA
ATGCTGAAATTCATGCTTGATACCAATACTTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCACCGG
AGCGTAATTTTGCAGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTACCGAACTGGCCCGCAAGGGAACACCTGTCGGGTCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10480.98 Da Isoelectric Point: 5.1116
>AT241994 WP_002916312.1 NZ_CP095428:4813384-4813650 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
Download Length: 267 bp
>AT241994 NZ_OU943336:821847-822074 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGCACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGCACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A378E4P6 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GY41 |