Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4813384..4814038 Replicon chromosome
Accession NZ_CP095428
Organism Klebsiella pneumoniae strain IM007

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag MWR71_RS23750 Protein ID WP_004144731.1
Coordinates 4813631..4814038 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MWR71_RS23745 Protein ID WP_002916312.1
Coordinates 4813384..4813650 (+) Length 89 a.a.

Genomic Context


MWR71_RS23730MWR71_RS23735MWR71_RS23745MWR71_RS23750MWR71_RS23760MWR71_RS23765MWR71_RS23770MWR71_RS23720MWR71_RS23725MWR71_RS23740MWR71_RS23755
Location: 4810870..4811181 (312 bp)
Type: Others
Protein ID: WP_002916319.1
Location: 4811345..4812004 (660 bp)
Type: Others
Protein ID: WP_002916317.1
Location: 4813384..4813650 (267 bp)
Type: Antitoxin
Protein ID: WP_002916312.1
Location: 4813631..4814038 (408 bp)
Type: Toxin
Protein ID: WP_004144731.1
Location: 4814667..4815563 (897 bp)
Type: Others
Protein ID: WP_004144729.1
Location: 4815586..4816299 (714 bp)
Type: Others
Protein ID: WP_002916301.1
Location: 4816305..4818038 (1734 bp)
Type: Others
Protein ID: WP_004151783.1
Location: 4808540..4809973 (1434 bp)
Type: Others
Protein ID: WP_002916322.1
Location: 4810092..4810820 (729 bp)
Type: Others
Protein ID: WP_002916321.1
Location: 4812155..4813138 (984 bp)
Type: Others
Protein ID: WP_002916313.1
Location: 4814045..4814566 (522 bp)
Type: Others
Protein ID: WP_002916308.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MWR71_RS23720 (MWR71_23690)4808540..4809973-1434WP_002916322.16-phospho-beta-glucosidase BglA-
MWR71_RS23725 (MWR71_23695)4810092..4810820-729WP_002916321.1MurR/RpiR family transcriptional regulator-
MWR71_RS23730 (MWR71_23700)4810870..4811181+312WP_002916319.1N(4)-acetylcytidine aminohydrolase-
MWR71_RS23735 (MWR71_23705)4811345..4812004+660WP_002916317.1hemolysin III family protein-
MWR71_RS23740 (MWR71_23710)4812155..4813138-984WP_002916313.1tRNA-modifying protein YgfZ-
MWR71_RS23745 (MWR71_23715)4813384..4813650+267WP_002916312.1FAD assembly factor SdhEAntitoxin
MWR71_RS23750 (MWR71_23720)4813631..4814038+408WP_004144731.1protein YgfXToxin
MWR71_RS23755 (MWR71_23725)4814045..4814566-522WP_002916308.1flavodoxin FldB-
MWR71_RS23760 (MWR71_23730)4814667..4815563+897WP_004144729.1site-specific tyrosine recombinase XerD-
MWR71_RS23765 (MWR71_23735)4815586..4816299+714WP_002916301.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
MWR71_RS23770 (MWR71_23740)4816305..4818038+1734WP_004151783.1single-stranded-DNA-specific exonuclease RecJ-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-131)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T241994 WP_004144731.1 NZ_CP095428:4813631-4814038 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T241994 NZ_OU943336:822074-822472 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCTGAAATTCATGCTTGATACCAATACTTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCACCGG
AGCGTAATTTTGCAGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTACCGAACTGGCCCGCAAGGGAACACCTGTCGGGTCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT241994 WP_002916312.1 NZ_CP095428:4813384-4813650 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT241994 NZ_OU943336:821847-822074 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGCACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A378E4P6


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GY41

References