Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3765414..3766039 Replicon chromosome
Accession NZ_CP095428
Organism Klebsiella pneumoniae strain IM007

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag MWR71_RS18545 Protein ID WP_002882817.1
Coordinates 3765414..3765797 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag MWR71_RS18550 Protein ID WP_004150355.1
Coordinates 3765797..3766039 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWR71_RS18530 (MWR71_18500) 3762780..3763682 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
MWR71_RS18535 (MWR71_18505) 3763679..3764314 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
MWR71_RS18540 (MWR71_18510) 3764311..3765240 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
MWR71_RS18545 (MWR71_18515) 3765414..3765797 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
MWR71_RS18550 (MWR71_18520) 3765797..3766039 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
MWR71_RS18555 (MWR71_18525) 3766244..3767161 + 918 WP_002882812.1 alpha/beta hydrolase -
MWR71_RS18560 (MWR71_18530) 3767175..3768116 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
MWR71_RS18565 (MWR71_18535) 3768161..3768598 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
MWR71_RS18570 (MWR71_18540) 3768595..3769455 - 861 WP_002882807.1 virulence factor BrkB family protein -
MWR71_RS18575 (MWR71_18545) 3769449..3770048 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T241990 WP_002882817.1 NZ_CP095428:c3765797-3765414 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T241990 NZ_OU943334:299867-300169 [Stenotrophomonas maltophilia]
ATGGTCATCAAGAGAAAAGTTCAACTCAAAGCATTTGATGTGGCCGAGCATCTTCGAACGCCGGAGGAAATGGCCGCCTA
TCTCGACGCCTGCATCGAAGAAAGCGACGGCGATTCTGCCTTCATCGCCAAGGCGCTCGGCGATATCGCCCGCGCTCAGG
GGATGAGCAAGGTTGCACGGGCGGCGGGTTTGTCGCGCGAGAGTCTGTACCGCGCACTGTCGGGCGAGCGCAGCCCGGAT
TTCGCCACCATCCTGAAGGTGACCCGGGCCCTGGGTGTGCGATTGCACGCCAGCGCTGTGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT241990 WP_004150355.1 NZ_CP095428:c3766039-3765797 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT241990 NZ_OU943334:299521-299808 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCCGGTGATCACCGCTATCTGGCGGATGGCGTTTCTGAATTGCGTATCGATG
CAGGACCGGGTTACCGCGTTTACTACACCCAGCGCGGCAGGCAGTTGGTGATTCTCCTGGTTGGAGGCGACAAGGGTTCG
CAGCAGCGCGATATAGAGAAGGCCAGGGAGATTGCGCGTGCCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References