Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3285186..3285702 Replicon chromosome
Accession NZ_CP095428
Organism Klebsiella pneumoniae strain IM007

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag MWR71_RS16240 Protein ID WP_002886902.1
Coordinates 3285186..3285470 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MWR71_RS16245 Protein ID WP_002886901.1
Coordinates 3285460..3285702 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWR71_RS16215 (MWR71_16185) 3280670..3280978 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
MWR71_RS16220 (MWR71_16190) 3281063..3281236 + 174 WP_002886906.1 hypothetical protein -
MWR71_RS16225 (MWR71_16195) 3281239..3281982 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MWR71_RS16230 (MWR71_16200) 3282339..3284477 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
MWR71_RS16235 (MWR71_16205) 3284718..3285182 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MWR71_RS16240 (MWR71_16210) 3285186..3285470 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MWR71_RS16245 (MWR71_16215) 3285460..3285702 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MWR71_RS16250 (MWR71_16220) 3285780..3287690 - 1911 WP_004152270.1 PRD domain-containing protein -
MWR71_RS16255 (MWR71_16225) 3287713..3288867 - 1155 WP_002886900.1 lactonase family protein -
MWR71_RS16260 (MWR71_16230) 3288933..3289673 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T241988 WP_002886902.1 NZ_CP095428:c3285470-3285186 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T241988 NZ_OU912926:2114364-2114630 [Candidatus Nitrotoga arctica]
TTGGCCTGGACAATTGATTACGCGGAGACGGCCAAAGCGCAGCTACGCAAGCTGGACAAGCAGACGGCGCGGCGCATCGT
TGATTTTATGGATGAGCGGGTCGCCGGACGGGAAAATCCGCGCGACTCAGGCAAAGCGCTGACCGGCTCGCTGGGTGGTT
TCTGGCGTTATCGCGTGCGCGACTGCCGGGTGATTTGCGACATTCAGGACGGTGTATTGCGCGTGCTCGTGGTGCAGGTT
GGCAACCGGCGCGAAATTTACCGATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT241988 WP_002886901.1 NZ_CP095428:c3285702-3285460 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT241988 NZ_OU912926:2114120-2114380 [Candidatus Nitrotoga arctica]
GTGAATACACGCATTCAACTGGAGACTCTTAATATGGCAACTTCAATTCGCCTTGCTCCTGAAATCGAGCAAAGGCTTGA
TTACCTCGCCTCCCATACCGGGCGCACCAAGGCGTACTATCTGCGCGAAATCATCGAGCATGGCATCGAGGAAATGGAGG
ACTATTACCTTGCCGCCGACGTGCTGGAGCGTGTCCGCAAGGGACAAGAACAGGTGCATTCCGCTGCTGACGTGAGAAAA
GACCTTGGCCTGGACAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References