Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 1107670..1109258 | Replicon | chromosome |
| Accession | NZ_CP095428 | ||
| Organism | Klebsiella pneumoniae strain IM007 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A0H3GN97 |
| Locus tag | MWR71_RS05425 | Protein ID | WP_004199851.1 |
| Coordinates | 1107670..1108992 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A0H3GXD8 |
| Locus tag | MWR71_RS05430 | Protein ID | WP_002904790.1 |
| Coordinates | 1108992..1109258 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MWR71_RS05410 (MWR71_05405) | 1102735..1105236 | + | 2502 | WP_004199853.1 | fimbria/pilus outer membrane usher protein | - |
| MWR71_RS05415 (MWR71_05410) | 1105224..1106228 | + | 1005 | WP_004199852.1 | fimbrial protein | - |
| MWR71_RS05420 (MWR71_05415) | 1106361..1107653 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
| MWR71_RS05425 (MWR71_05420) | 1107670..1108992 | - | 1323 | WP_004199851.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| MWR71_RS05430 (MWR71_05425) | 1108992..1109258 | - | 267 | WP_002904790.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| MWR71_RS05435 (MWR71_05430) | 1109524..1109850 | - | 327 | WP_002904788.1 | hydroxyisourate hydrolase | - |
| MWR71_RS05440 (MWR71_05435) | 1109847..1110347 | - | 501 | WP_002904787.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| MWR71_RS05445 (MWR71_05440) | 1110325..1111704 | - | 1380 | WP_004199850.1 | nucleobase:cation symporter-2 family protein | - |
| MWR71_RS05450 (MWR71_05445) | 1112050..1113204 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
| MWR71_RS05455 (MWR71_05450) | 1113185..1114108 | - | 924 | WP_004199849.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49128.44 Da Isoelectric Point: 7.2487
>T241985 WP_004199851.1 NZ_CP095428:c1108992-1107670 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T241985 NZ_OU912926:585321-585596 [Candidatus Nitrotoga arctica]
ATGATTGAATCGTTCATGCACAAGGGACTGGAAGAGCTTTTCGAAAAAGGCAAGAGCGCTAAGGTGCAGCAAGCCTTGGT
GGGGCGCGCATTGCGGCGACTGGATGCCATCAACACCGCCAAAACACCGGACGTGTTGAATCTTCCGGGCTTCGACTTCC
ATCTCTTGCAGGGCACGCCCAAGCGATACAGCGTGCATGTAAATAGGCCGTGGTTTATTACATTCGAATGGGAAGGCGAG
AATGCGCTACGGATCAATTTGGAAAACTATCACTAG
ATGATTGAATCGTTCATGCACAAGGGACTGGAAGAGCTTTTCGAAAAAGGCAAGAGCGCTAAGGTGCAGCAAGCCTTGGT
GGGGCGCGCATTGCGGCGACTGGATGCCATCAACACCGCCAAAACACCGGACGTGTTGAATCTTCCGGGCTTCGACTTCC
ATCTCTTGCAGGGCACGCCCAAGCGATACAGCGTGCATGTAAATAGGCCGTGGTTTATTACATTCGAATGGGAAGGCGAG
AATGCGCTACGGATCAATTTGGAAAACTATCACTAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 9906.27 Da Isoelectric Point: 8.5912
>AT241985 WP_002904790.1 NZ_CP095428:c1109258-1108992 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
Download Length: 267 bp
>AT241985 NZ_OU912926:585605-585910 [Candidatus Nitrotoga arctica]
ATGCGGAAACGTAAACCGACTCACCCCGGCGCGATCTTGCGCGAAGACGTTCTGCCAGACTTGGGAATGTCTGTAAGCGC
CTTTGCTCGCAATCTTGGAGTCTCGCGCCAAACCCTGCATGCGATACTGGCAGAGCGTAGCGGCATCTCCCCGGAAATGG
CGCTCCGTTTGGGTGCATTGCTAGGTAATGGCGCTCAGTTGTGGGTGGACATGCAATCGAAATACGATCTATGGCAGGCT
GAGGATAAACTTCACGACGTGCTGTCGAGTATCCAATGCCTTACCGACAACCAGGCATTGGCTTGA
ATGCGGAAACGTAAACCGACTCACCCCGGCGCGATCTTGCGCGAAGACGTTCTGCCAGACTTGGGAATGTCTGTAAGCGC
CTTTGCTCGCAATCTTGGAGTCTCGCGCCAAACCCTGCATGCGATACTGGCAGAGCGTAGCGGCATCTCCCCGGAAATGG
CGCTCCGTTTGGGTGCATTGCTAGGTAATGGCGCTCAGTTGTGGGTGGACATGCAATCGAAATACGATCTATGGCAGGCT
GAGGATAAACTTCACGACGTGCTGTCGAGTATCCAATGCCTTACCGACAACCAGGCATTGGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GN97 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GXD8 |