Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5223496..5225177 Replicon chromosome
Accession NZ_CP095426
Organism Klebsiella pneumoniae strain IM029

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag MWR69_RS25995 Protein ID WP_002885155.1
Coordinates 5223496..5224413 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag MWR69_RS26000 Protein ID WP_004151732.1
Coordinates 5224419..5225177 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWR69_RS25975 (MWR69_25945) 5218802..5220322 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
MWR69_RS25980 (MWR69_25950) 5220319..5221317 + 999 WP_002885172.1 ribose ABC transporter permease -
MWR69_RS25985 (MWR69_25955) 5221348..5222289 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
MWR69_RS25990 (MWR69_25960) 5222364..5223371 + 1008 WP_004151731.1 carbohydrate kinase family protein -
MWR69_RS25995 (MWR69_25965) 5223496..5224413 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
MWR69_RS26000 (MWR69_25970) 5224419..5225177 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
MWR69_RS26005 (MWR69_25975) 5225263..5225991 - 729 WP_002885152.1 response regulator transcription factor -
MWR69_RS26010 (MWR69_25980) 5226264..5228411 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
MWR69_RS26015 (MWR69_25985) 5228641..5229327 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 / qnrB4 / blaDHA-1 / mph(A) / blaTEM-1B / blaCTX-M-15 / aac(6')-Ib-cr / blaOXA-1 / tet(A) / blaSHV-187 / aph(3')-Ia iucA / iucB / iucC / iucD / iutA / rmpA 4994180..5228537 234357


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T241967 WP_002885155.1 NZ_CP095426:c5224413-5223496 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T241967 NZ_OU701460:c36433-36158 [Campylobacter upsaliensis]
ATGCGTAAGCAAGTTTTTCAAAACGCTTTTAAAAGAGATTTGAAACTTGTTAGAAAACAAAGTTGGGATATTAAAGCAAT
ACAAAAATGTGTAGAGGATTTAGCCATACTAGATATTCTGCCAAAGAAGTATGAAGACCACCCATTAAAAGGCGACCTGA
AGGAATTTAGAGAGTGCCACATCTTTGGGGACTTGGTGATAATCTACAAAAGAAACAATAAAGAAATTAATTATTATCGC
ATAGGCAGACACCAAGATTTATTTAAAAAATACTAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT241967 WP_004151732.1 NZ_CP095426:c5225177-5224419 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT241967 NZ_OU701460:c36737-36426 [Campylobacter upsaliensis]
ATGTATAATTATGCTAAGTATGAAAACGCCACAAGAAAAGACATTATTAAGGCTCTTAATTTAGCAGAAAAAAAAGAAAA
AAAACTACAAGAACAGCTAAAAGAAAACAAAGAATTTTTTAAATTTTTACAAAAGAAATTCAATGAAAGTTTTAACCCTT
TAAGACAAGTAAAAACTAAAAAACAAAAGAAATATGATGAGCCGACTGAAGAAACAAAATTAATTTTAGCTAAAAATGAA
CCAACAAAATATAACAATTTTAATGACTTGCTAAATGCTATTGATGATGAGCTTAAGGCTGACAATGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References