Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4875377..4875893 Replicon chromosome
Accession NZ_CP095426
Organism Klebsiella pneumoniae strain IM029

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag MWR69_RS24150 Protein ID WP_002886902.1
Coordinates 4875377..4875661 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MWR69_RS24155 Protein ID WP_002886901.1
Coordinates 4875651..4875893 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWR69_RS24125 (MWR69_24095) 4870861..4871124 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
MWR69_RS24130 (MWR69_24100) 4871254..4871427 + 174 WP_002886906.1 hypothetical protein -
MWR69_RS24135 (MWR69_24105) 4871430..4872173 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MWR69_RS24140 (MWR69_24110) 4872530..4874668 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
MWR69_RS24145 (MWR69_24115) 4874909..4875373 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MWR69_RS24150 (MWR69_24120) 4875377..4875661 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MWR69_RS24155 (MWR69_24125) 4875651..4875893 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MWR69_RS24160 (MWR69_24130) 4875971..4877881 - 1911 WP_004152270.1 PRD domain-containing protein -
MWR69_RS24165 (MWR69_24135) 4877904..4879058 - 1155 WP_002886900.1 lactonase family protein -
MWR69_RS24170 (MWR69_24140) 4879124..4879864 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T241964 WP_002886902.1 NZ_CP095426:c4875661-4875377 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T241964 NZ_OU701452:4793235-4793408 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT241964 WP_002886901.1 NZ_CP095426:c4875893-4875651 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT241964 NZ_OU701452:4792911-4793207 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References