Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 876502..877156 Replicon chromosome
Accession NZ_CP095426
Organism Klebsiella pneumoniae strain IM029

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag MWR69_RS04425 Protein ID WP_004144731.1
Coordinates 876749..877156 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MWR69_RS04420 Protein ID WP_002916312.1
Coordinates 876502..876768 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWR69_RS04395 (MWR69_04395) 871658..873091 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
MWR69_RS04400 (MWR69_04400) 873210..873938 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MWR69_RS04405 (MWR69_04405) 873988..874299 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
MWR69_RS04410 (MWR69_04410) 874463..875122 + 660 WP_002916317.1 hemolysin III family protein -
MWR69_RS04415 (MWR69_04415) 875273..876256 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MWR69_RS04420 (MWR69_04420) 876502..876768 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MWR69_RS04425 (MWR69_04425) 876749..877156 + 408 WP_004144731.1 protein YgfX Toxin
MWR69_RS04430 (MWR69_04430) 877163..877684 - 522 WP_002916308.1 flavodoxin FldB -
MWR69_RS04435 (MWR69_04435) 877785..878681 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MWR69_RS04440 (MWR69_04440) 878704..879417 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MWR69_RS04445 (MWR69_04445) 879423..881156 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T241952 WP_004144731.1 NZ_CP095426:876749-877156 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T241952 NZ_OU701452:c2310295-2310044 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT241952 WP_002916312.1 NZ_CP095426:876502-876768 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT241952 NZ_OU701452:c2310047-2309793 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References