Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relB-parE/ParE-RHH |
Location | 4057..4637 | Replicon | plasmid pIM057_4 |
Accession | NZ_CP095425 | ||
Organism | Klebsiella pneumoniae strain IM057 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A8J3DTL7 |
Locus tag | MWR70_RS29550 | Protein ID | WP_071177730.1 |
Coordinates | 4057..4371 (-) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A2X1PRM1 |
Locus tag | MWR70_RS29555 | Protein ID | WP_000093040.1 |
Coordinates | 4359..4637 (-) | Length | 93 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MWR70_RS29525 (MWR70_29490) | 1..1965 | + | 1965 | WP_071177727.1 | TraM recognition domain-containing protein | - |
MWR70_RS29530 (MWR70_29495) | 1965..2696 | + | 732 | WP_071177728.1 | MobC family replication-relaxation protein | - |
MWR70_RS29535 (MWR70_29500) | 2703..3233 | + | 531 | WP_071177729.1 | hypothetical protein | - |
MWR70_RS29540 (MWR70_29505) | 3260..3439 | - | 180 | WP_000165970.1 | Rop family plasmid primer RNA-binding protein | - |
MWR70_RS29545 (MWR70_29510) | 3465..3893 | - | 429 | WP_001140599.1 | hypothetical protein | - |
MWR70_RS29550 (MWR70_29515) | 4057..4371 | - | 315 | WP_071177730.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
MWR70_RS29555 (MWR70_29520) | 4359..4637 | - | 279 | WP_000093040.1 | CopG family ribbon-helix-helix protein | Antitoxin |
MWR70_RS29560 (MWR70_29525) | 4812..5177 | - | 366 | WP_072354022.1 | TonB family protein | - |
MWR70_RS29565 (MWR70_29530) | 5174..5545 | - | 372 | WP_001237044.1 | cell envelope integrity protein TolA | - |
MWR70_RS29570 (MWR70_29535) | 5819..6064 | - | 246 | WP_032440458.1 | hypothetical protein | - |
MWR70_RS29575 (MWR70_29540) | 6391..8076 | + | 1686 | WP_032440457.1 | colicin-like bacteriocin tRNase domain-containing protein | - |
MWR70_RS29580 (MWR70_29545) | 8086..8343 | + | 258 | WP_032440455.1 | colicin E3-like toxin immunity protein | - |
MWR70_RS29585 (MWR70_29550) | 8428..8577 | + | 150 | WP_032440454.1 | colicin release lysis protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..10060 | 10060 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11805.73 Da Isoelectric Point: 9.8324
>T241948 WP_071177730.1 NZ_CP095425:c4371-4057 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL
Download Length: 315 bp
>T241948 NZ_OU701452:1593471-1593647 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10709.73 Da Isoelectric Point: 4.7561
>AT241948 WP_000093040.1 NZ_CP095425:c4637-4359 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR
Download Length: 279 bp
>AT241948 NZ_OU701452:1593693-1594109 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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