Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4057..4637 Replicon plasmid pIM057_4
Accession NZ_CP095425
Organism Klebsiella pneumoniae strain IM057

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag MWR70_RS29550 Protein ID WP_071177730.1
Coordinates 4057..4371 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag MWR70_RS29555 Protein ID WP_000093040.1
Coordinates 4359..4637 (-) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWR70_RS29525 (MWR70_29490) 1..1965 + 1965 WP_071177727.1 TraM recognition domain-containing protein -
MWR70_RS29530 (MWR70_29495) 1965..2696 + 732 WP_071177728.1 MobC family replication-relaxation protein -
MWR70_RS29535 (MWR70_29500) 2703..3233 + 531 WP_071177729.1 hypothetical protein -
MWR70_RS29540 (MWR70_29505) 3260..3439 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
MWR70_RS29545 (MWR70_29510) 3465..3893 - 429 WP_001140599.1 hypothetical protein -
MWR70_RS29550 (MWR70_29515) 4057..4371 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MWR70_RS29555 (MWR70_29520) 4359..4637 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
MWR70_RS29560 (MWR70_29525) 4812..5177 - 366 WP_072354022.1 TonB family protein -
MWR70_RS29565 (MWR70_29530) 5174..5545 - 372 WP_001237044.1 cell envelope integrity protein TolA -
MWR70_RS29570 (MWR70_29535) 5819..6064 - 246 WP_032440458.1 hypothetical protein -
MWR70_RS29575 (MWR70_29540) 6391..8076 + 1686 WP_032440457.1 colicin-like bacteriocin tRNase domain-containing protein -
MWR70_RS29580 (MWR70_29545) 8086..8343 + 258 WP_032440455.1 colicin E3-like toxin immunity protein -
MWR70_RS29585 (MWR70_29550) 8428..8577 + 150 WP_032440454.1 colicin release lysis protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10060 10060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T241948 WP_071177730.1 NZ_CP095425:c4371-4057 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

>T241948 NZ_OU701452:1593471-1593647 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT241948 WP_000093040.1 NZ_CP095425:c4637-4359 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp

>AT241948 NZ_OU701452:1593693-1594109 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References