Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4944076..4944592 Replicon chromosome
Accession NZ_CP095421
Organism Klebsiella pneumoniae strain IM057

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag MWR70_RS24530 Protein ID WP_002886902.1
Coordinates 4944076..4944360 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MWR70_RS24535 Protein ID WP_002886901.1
Coordinates 4944350..4944592 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWR70_RS24505 (MWR70_24475) 4939560..4939823 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
MWR70_RS24510 (MWR70_24480) 4939953..4940126 + 174 WP_002886906.1 hypothetical protein -
MWR70_RS24515 (MWR70_24485) 4940129..4940872 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MWR70_RS24520 (MWR70_24490) 4941229..4943367 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
MWR70_RS24525 (MWR70_24495) 4943608..4944072 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MWR70_RS24530 (MWR70_24500) 4944076..4944360 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MWR70_RS24535 (MWR70_24505) 4944350..4944592 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MWR70_RS24540 (MWR70_24510) 4944670..4946580 - 1911 WP_004152270.1 PRD domain-containing protein -
MWR70_RS24545 (MWR70_24515) 4946603..4947757 - 1155 WP_002886900.1 lactonase family protein -
MWR70_RS24550 (MWR70_24520) 4947823..4948563 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T241935 WP_002886902.1 NZ_CP095421:c4944360-4944076 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T241935 NZ_OU701449:c4002433-4002035 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT241935 WP_002886901.1 NZ_CP095421:c4944592-4944350 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT241935 NZ_OU701449:c4002729-4002436 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References