Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2908317..2908942 Replicon chromosome
Accession NZ_CP095412
Organism Blastococcus sp. PRF04-17

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MVA48_RS14685 Protein ID WP_246981435.1
Coordinates 2908541..2908942 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MVA48_RS14680 Protein ID WP_246981434.1
Coordinates 2908317..2908544 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MVA48_RS14655 (MVA48_14655) 2904089..2904346 + 258 WP_246981428.1 hypothetical protein -
MVA48_RS14660 (MVA48_14660) 2904343..2904720 + 378 WP_246981429.1 VTT domain-containing protein -
MVA48_RS14665 (MVA48_14665) 2904717..2905292 + 576 WP_246981430.1 phage holin family protein -
MVA48_RS14670 (MVA48_14670) 2905181..2906854 + 1674 WP_246981431.1 alkaline phosphatase family protein -
MVA48_RS14675 (MVA48_14675) 2907018..2907887 - 870 WP_246981432.1 hypothetical protein -
MVA48_RS14680 (MVA48_14680) 2908317..2908544 + 228 WP_246981434.1 antitoxin Antitoxin
MVA48_RS14685 (MVA48_14685) 2908541..2908942 + 402 WP_246981435.1 VapC toxin family PIN domain ribonuclease Toxin
MVA48_RS14690 (MVA48_14690) 2908977..2909177 - 201 WP_246981437.1 hypothetical protein -
MVA48_RS14695 (MVA48_14695) 2909313..2909510 - 198 WP_246981439.1 hypothetical protein -
MVA48_RS14700 (MVA48_14700) 2909688..2910674 + 987 WP_246981440.1 glucosyl-3-phosphoglycerate synthase -
MVA48_RS14705 (MVA48_14705) 2910742..2911587 + 846 WP_246981442.1 glycerophosphodiester phosphodiesterase family protein -
MVA48_RS14710 (MVA48_14710) 2911584..2912249 - 666 WP_246981444.1 HAD family hydrolase -
MVA48_RS14715 (MVA48_14715) 2912309..2912707 + 399 WP_246981446.1 DUF5946 family protein -
MVA48_RS14720 (MVA48_14720) 2912721..2913449 + 729 WP_246981448.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14476.48 Da        Isoelectric Point: 4.8931

>T241918 WP_246981435.1 NZ_CP095412:2908541-2908942 [Blastococcus sp. PRF04-17]
VTVLLDANVLVALSVTDHVHHDVVEDWFVQLSEPFATCPLTQGALVRFMLRVGATARDAVEIVRGLGGADGHEFWPDELG
YDAVDMRGVVGHKQVTDAYLAGLVRLRRGRLATLDRALAAVHEDVALLLDSDH

Download         Length: 402 bp

>T241918 NZ_OU701449:217181-217288 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 7975.93 Da        Isoelectric Point: 5.0022

>AT241918 WP_246981434.1 NZ_CP095412:2908317-2908544 [Blastococcus sp. PRF04-17]
MRTTVDLPEDIHRLASAIARDSGSSLSETITRLLRGALAAPGPVRVTTSSRTGLQVASIGRVVTSEDVRTLEDDE

Download         Length: 228 bp

>AT241918 NZ_OU701449:c217132-217069 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References