Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpK-mazE/MazF(toxin)
Location 2891752..2892359 Replicon chromosome
Accession NZ_CP095412
Organism Blastococcus sp. PRF04-17

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag MVA48_RS14605 Protein ID WP_246981410.1
Coordinates 2892015..2892359 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MVA48_RS14600 Protein ID WP_246981408.1
Coordinates 2891752..2892018 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MVA48_RS14580 (MVA48_14580) 2887706..2889169 - 1464 WP_246981401.1 lipopolysaccharide biosynthesis protein -
MVA48_RS14585 (MVA48_14585) 2889604..2890008 - 405 WP_246981403.1 hypothetical protein -
MVA48_RS14590 (MVA48_14590) 2889975..2890640 - 666 WP_246981405.1 polysulfide reductase NrfD -
MVA48_RS14595 (MVA48_14595) 2890642..2891706 - 1065 WP_246981406.1 4Fe-4S dicluster domain-containing protein -
MVA48_RS14600 (MVA48_14600) 2891752..2892018 + 267 WP_246981408.1 ribbon-helix-helix domain-containing protein Antitoxin
MVA48_RS14605 (MVA48_14605) 2892015..2892359 + 345 WP_246981410.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MVA48_RS14610 (MVA48_14610) 2892458..2895691 - 3234 Protein_2905 molybdopterin-dependent oxidoreductase -
MVA48_RS14620 (MVA48_14620) 2895999..2896838 + 840 WP_246981416.1 SGNH/GDSL hydrolase family protein -
MVA48_RS14625 (MVA48_14625) 2896842..2897060 - 219 WP_246981418.1 hypothetical protein -
MVA48_RS14630 (MVA48_14630) 2897115..2897327 - 213 WP_246981421.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2886248..2887480 1232


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12229.34 Da        Isoelectric Point: 11.1986

>T241917 WP_246981410.1 NZ_CP095412:2892015-2892359 [Blastococcus sp. PRF04-17]
VIQRGQVRWADLGPPRGSAPALRRPVLVVQIDRLSRSRIATVAVVILTSNLRLAEVPGNVLVKPEDSGLPDPSVVNVSQL
VSVDKAFLDDQPRGLLPLDVMARVDAGLRLVLGL

Download         Length: 345 bp

>T241917 NZ_OU701449:216697-216804 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9595.54 Da        Isoelectric Point: 4.4128

>AT241917 WP_246981408.1 NZ_CP095412:2891752-2892018 [Blastococcus sp. PRF04-17]
VKTAISIPDHTFAEADRRARELGLNRSQFVTRAIERYLNELAEGDDLTDRINAALDAAGPEDPDDIAVRKAATRAAFARL
DAEDGGWA

Download         Length: 267 bp

>AT241917 NZ_OU701449:c216639-216585 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References