Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 671308..671924 Replicon chromosome
Accession NZ_CP095412
Organism Blastococcus sp. PRF04-17

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MVA48_RS03390 Protein ID WP_246985832.1
Coordinates 671517..671924 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MVA48_RS03385 Protein ID WP_246985830.1
Coordinates 671308..671520 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MVA48_RS03365 (MVA48_03365) 666344..666976 + 633 WP_246985822.1 DUF4956 domain-containing protein -
MVA48_RS03370 (MVA48_03370) 666973..667773 + 801 WP_246985824.1 polyphosphate polymerase domain-containing protein -
MVA48_RS03375 (MVA48_03375) 667770..669590 + 1821 WP_246985826.1 carbohydrate-binding domain-containing protein -
MVA48_RS03380 (MVA48_03380) 669720..670337 + 618 WP_246985828.1 hypothetical protein -
MVA48_RS03385 (MVA48_03385) 671308..671520 + 213 WP_246985830.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MVA48_RS03390 (MVA48_03390) 671517..671924 + 408 WP_246985832.1 PIN domain-containing protein Toxin
MVA48_RS03395 (MVA48_03395) 672414..672650 - 237 WP_246985834.1 excisionase family DNA-binding protein -
MVA48_RS03400 (MVA48_03400) 672847..673014 - 168 WP_246985836.1 hypothetical protein -
MVA48_RS03405 (MVA48_03405) 673935..674183 + 249 WP_246985838.1 hypothetical protein -
MVA48_RS03410 (MVA48_03410) 674466..675638 + 1173 WP_246985840.1 hypothetical protein -
MVA48_RS03415 (MVA48_03415) 675638..676060 + 423 WP_246985842.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 670403..694823 24420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(5-45)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14538.65 Da        Isoelectric Point: 4.5819

>T241916 WP_246985832.1 NZ_CP095412:671517-671924 [Blastococcus sp. PRF04-17]
VILADTSAWVEFDRATGSAVDRRMTELIAVDGPLAVTEPVLMEVLAGARDDQRADDLRRLLLRCHLLGIDPAADFDAAAR
VYRRCRRVGVTPRGLLDCLVVAVAWRSGASVLAQDVDVDRICDVLGVPSDPGATN

Download         Length: 408 bp

>T241916 NZ_OU701449:161180-161365 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7843.97 Da        Isoelectric Point: 5.6726

>AT241916 WP_246985830.1 NZ_CP095412:671308-671520 [Blastococcus sp. PRF04-17]
MPRLRTNIEIEDELVQVVMTRYAVRTKTEAVDLALRHLAGQPMSRDEALSMRGARAMEDVPEDHAPRGAA

Download         Length: 213 bp

>AT241916 NZ_OU701449:161382-161792 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGTGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References