Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 51591..52147 Replicon chromosome
Accession NZ_CP095412
Organism Blastococcus sp. PRF04-17

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MVA48_RS00275 Protein ID WP_246984417.1
Coordinates 51591..51908 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MVA48_RS00280 Protein ID WP_246984419.1
Coordinates 51908..52147 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MVA48_RS00260 (MVA48_00260) 46629..47999 + 1371 WP_246984411.1 SWIM zinc finger family protein -
MVA48_RS00265 (MVA48_00265) 47957..49840 + 1884 WP_246984413.1 DEAD/DEAH box helicase -
MVA48_RS00270 (MVA48_00270) 49995..51092 - 1098 WP_246984415.1 DUF222 domain-containing protein -
MVA48_RS00275 (MVA48_00275) 51591..51908 - 318 WP_246984417.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MVA48_RS00280 (MVA48_00280) 51908..52147 - 240 WP_246984419.1 ribbon-helix-helix domain-containing protein Antitoxin
MVA48_RS00285 (MVA48_00285) 52296..52880 - 585 WP_246984421.1 DUF6398 domain-containing protein -
MVA48_RS00290 (MVA48_00290) 53011..54147 + 1137 WP_246984423.1 hypothetical protein -
MVA48_RS00295 (MVA48_00295) 54232..55407 + 1176 WP_246984425.1 IS110 family transposase -
MVA48_RS00300 (MVA48_00300) 55891..56778 - 888 WP_246984426.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11332.31 Da        Isoelectric Point: 7.3611

>T241915 WP_246984417.1 NZ_CP095412:c51908-51591 [Blastococcus sp. PRF04-17]
MRPIHLASLDKTRPVLILTRELVRPHLARVTVAPITSTIRGLSTEVLVGPVNGLDHPSVISCDNVATIPTAALGRQIGRL
LPEQEPLLTAALHAAFDLEELPPLR

Download         Length: 318 bp

>T241915 NZ_OU659204:c3925699-3924380 [Providencia alcalifaciens]
ATGGCAATTTTGCATGTGTATATGAATGGTTATCTCGTTGGGGAATTTATTCATTCAAGTACCGGGGCTCATCAATTTAA
GTATGATAATCATTGGTTAGAAATGCCGGGAACTCGTCCTATTTCTTTGTCAATGCCACTTCAACATAAGGAATACAAAG
GGGACGAAGTCTATAATTTTTTTGACAATCTCCTACCGGATAATATTGAAATACGAAATCGAATTGTTAGTCGCCATCAA
GCGAATTCAAATCAACCTTTCGATTTATTATCCAAAATTGGGCAAGATAGTGTGGGAGCTTTGCAACTAGTTCCTGCTGG
GCAAACAGTGAGTAATGTAAAACAAATCGAATATAAGCGTTTATCCACTGAAAAATTAGAAAAAATCTTAACTGGATATA
AAGCGAATATTCCATTGGGTATGATTGAAGAAGAGGATGATTTTAGGATCTCGATTGCTGGAGCACAGGAGAAAACTGCA
CTACTCAATTTAGATAGGTATTGGTGTCTGCCCCTGAATGCAACCCCAACAACCCATATTATTAAGCTCCCTATTGGTAA
GATAGAAAGCCACTCATATTCAATTGATATGTCTGATAGTGTAGAAAATGAGCATCTATGTTTATTGATAGCAAAAGCAT
TCGGTCTAGATGTACCCCACAGTTTTATTTTAAATGTGGGTAAGATAAAGGCGTTAGCCGTTGAGCGTTTTGACCGTAAA
TATTCTTCTGACTATTCGTGGATTATGCGCTTACCACAGGAAGATTTTTGTCAAACCCTGAATGTTTCGCCAGCAATAAA
ATATCAAAGTCATGGCGGACCCGGTATTCAGGATATAATGGATTATCTACTGGGTTCAATAAACGCAGAGAAAGATAGAT
ATCAATTTATGAAAAGCCAAGTTCTGTTTTGGCTACTTGCAGCGACCGACGGACACGCTAAAAATTTTTCATTGTTTATT
GAATCGGAGGGGCGTTACCAATTAACACCTTTCTACGATATTTTATCGATGTATCCCAGTTATGGTGGTAGAGGGCTAAA
TCCTAGAGACGCAAAACTTGCTATGGGATTAAAAGGGAAAAAAGGGATTAAGTACGAAATAGAGCAAATTTTTCCACGAC
ATTTTTTTGCTACCGCGAAAGCGGTTGGTTTTGACCGCACTGAAATGGAAAAGATCTTAATTGAGTTTGATGAGCAAATG
GAAAGTGTAATTACGAAAGTTAGCGAACAGCTTCCAACAGATTTTCCTGAACATATTGCAAACTCAATTTTATCAGGATT
ACATCAAAAAGCTGCTCGATTAAAAAAAGGTTGGGATTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8656.74 Da        Isoelectric Point: 4.4857

>AT241915 WP_246984419.1 NZ_CP095412:c52147-51908 [Blastococcus sp. PRF04-17]
MTTQIAVRLPEELVEFVDRLVSDGRAPSRAAVVSRALHRELRREVAARDAAILAATGTEADDLDELARYGARVPLDDLD

Download         Length: 240 bp

>AT241915 NZ_OU659204:c3925956-3925699 [Providencia alcalifaciens]
ATGAAAATCACCAATACTCGACAACTTAGCGCGTACATGAAAGATGTCAGAGAAACGAAAAAACTATCTCAAAGCAAAGT
CGCGAGTAAAGTGGGTATTCGGCAAGATACCGTCTCCAGTTTTGAATGTTCTCCTGACTCTACAAAATTAGAAACTTTCT
TTAAAATTTTATCCGCGTTAAATCTAGAACTCGATATTAAACCCAGAAATGAAAGTGGCTCATCCAACACCGACTCCGGA
TGGAAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References