Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PumAB/upstrm_HI1419-dnstrm_HI1420 |
| Location | 29808..30392 | Replicon | plasmid pTCM-1 |
| Accession | NZ_CP095408 | ||
| Organism | Acinetobacter pittii strain TCM | ||
Toxin (Protein)
| Gene name | PumA | Uniprot ID | N9JY46 |
| Locus tag | MWH18_RS21160 | Protein ID | WP_000286963.1 |
| Coordinates | 30090..30392 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | PumB | Uniprot ID | - |
| Locus tag | MWH18_RS21155 | Protein ID | WP_000985610.1 |
| Coordinates | 29808..30089 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MWH18_RS21115 (MWH18_21110) | 25312..25440 | + | 129 | WP_002123981.1 | AAA family ATPase | - |
| MWH18_RS21120 (MWH18_21115) | 25494..25700 | + | 207 | WP_233728806.1 | AAA family ATPase | - |
| MWH18_RS21125 (MWH18_21120) | 25628..26173 | + | 546 | Protein_37 | IS5-like element ISAba13 family transposase | - |
| MWH18_RS21130 (MWH18_21125) | 26930..27148 | + | 219 | WP_029747731.1 | hypothetical protein | - |
| MWH18_RS21135 (MWH18_21130) | 27258..27467 | - | 210 | WP_000069471.1 | hypothetical protein | - |
| MWH18_RS21140 (MWH18_21135) | 27460..27762 | - | 303 | WP_001140619.1 | XRE family transcriptional regulator | - |
| MWH18_RS21145 (MWH18_21140) | 27755..28111 | - | 357 | WP_006581604.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MWH18_RS21150 (MWH18_21145) | 28732..29604 | - | 873 | WP_006581603.1 | restriction endonuclease | - |
| MWH18_RS21155 (MWH18_21150) | 29808..30089 | - | 282 | WP_000985610.1 | putative addiction module antidote protein | Antitoxin |
| MWH18_RS21160 (MWH18_21155) | 30090..30392 | - | 303 | WP_000286963.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MWH18_RS21165 (MWH18_21160) | 30584..30976 | + | 393 | WP_228713465.1 | hypothetical protein | - |
| MWH18_RS21170 (MWH18_21165) | 30988..31920 | - | 933 | WP_002048759.1 | IS5 family transposase | - |
| MWH18_RS21175 (MWH18_21170) | 31974..32453 | + | 480 | Protein_47 | GIY-YIG nuclease family protein | - |
| MWH18_RS21180 (MWH18_21175) | 32653..33015 | - | 363 | Protein_48 | plasmid replication DNA-binding protein | - |
| MWH18_RS21185 (MWH18_21180) | 33049..33273 | - | 225 | WP_125510319.1 | hypothetical protein | - |
| MWH18_RS21190 (MWH18_21185) | 33510..34718 | + | 1209 | WP_004832869.1 | IS256-like element ISAba26 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | sul2 | - | 1..84108 | 84108 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11545.02 Da Isoelectric Point: 4.6838
>T241912 WP_000286963.1 NZ_CP095408:c30392-30090 [Acinetobacter pittii]
MYSIYTTEAFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL
MYSIYTTEAFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL
Download Length: 303 bp
>T241912 NZ_OU659204:c3581136-3580717 [Providencia alcalifaciens]
GTGACAAAACTCTACATGCTTGATACCAATATTTGCTCTTTCATTATGAGAGAGCAACCCATGTATCTACTACAGAGACT
GCAAGATTGTGTTATGCATCGACATTCTATTGTTATTTCTGCGATTACTTATTCAGAAATGCGCTTTGGGGCGATAGGTA
AAAAAGCCTCACTTAAGCATAATTTTTTAGTCGATGCATTTTGTGAGCGTCTTGATGGCGTTCTTACTTGGGATAAAGAT
GCAATTGATGCAACAACGGCAATTAAGAAAGCATTATCGGAAGCCGGAACGCCTATTGGCAATAATGATACTGCAATAGC
CGGTCATGCATTAGCAACTAACTCTATATTGGTGACTAACAATACCCGAGAGTTTTCACGAGTATTGGGATTGAAACTAG
AAGATTGGTTGCAGCCATAG
GTGACAAAACTCTACATGCTTGATACCAATATTTGCTCTTTCATTATGAGAGAGCAACCCATGTATCTACTACAGAGACT
GCAAGATTGTGTTATGCATCGACATTCTATTGTTATTTCTGCGATTACTTATTCAGAAATGCGCTTTGGGGCGATAGGTA
AAAAAGCCTCACTTAAGCATAATTTTTTAGTCGATGCATTTTGTGAGCGTCTTGATGGCGTTCTTACTTGGGATAAAGAT
GCAATTGATGCAACAACGGCAATTAAGAAAGCATTATCGGAAGCCGGAACGCCTATTGGCAATAATGATACTGCAATAGC
CGGTCATGCATTAGCAACTAACTCTATATTGGTGACTAACAATACCCGAGAGTTTTCACGAGTATTGGGATTGAAACTAG
AAGATTGGTTGCAGCCATAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10109.67 Da Isoelectric Point: 8.0018
>AT241912 WP_000985610.1 NZ_CP095408:c30089-29808 [Acinetobacter pittii]
MAIKLRKWDSAEHLKTEEDMQAYLQACIDESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI
MAIKLRKWDSAEHLKTEEDMQAYLQACIDESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI
Download Length: 282 bp
>AT241912 NZ_OU659204:c3581366-3581133 [Providencia alcalifaciens]
ATGGTAACTAAAATTGTTGCTGTATTTAAAAATGGTAATAATCGCGCAGTTCGTTTACCTAAAGATATTGATTTTGAAGG
TGTAAATGAATTAGAGATTAGTCGTGAAGGGAATCGTATTATTCTTCGTCCAGTCAAACCTAATTGGCTATCACTAAGAG
ATGAAGATAAAGCAGACAAAGATTTCTTACTTGAACGTGAAGACGTGATTGAAGATGGAAGGATAGTTTTGTGA
ATGGTAACTAAAATTGTTGCTGTATTTAAAAATGGTAATAATCGCGCAGTTCGTTTACCTAAAGATATTGATTTTGAAGG
TGTAAATGAATTAGAGATTAGTCGTGAAGGGAATCGTATTATTCTTCGTCCAGTCAAACCTAATTGGCTATCACTAAGAG
ATGAAGATAAAGCAGACAAAGATTTCTTACTTGAACGTGAAGACGTGATTGAAGATGGAAGGATAGTTTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|