Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 2944226..2945946 Replicon chromosome
Accession NZ_CP095407
Organism Acinetobacter pittii strain TCM

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag MWH18_RS14470 Protein ID WP_087537449.1
Coordinates 2945287..2945946 (-) Length 220 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag MWH18_RS14465 Protein ID WP_087537450.1
Coordinates 2944226..2945290 (-) Length 355 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWH18_RS14455 (MWH18_14455) 2939562..2940833 + 1272 WP_087537453.1 site-specific integrase -
MWH18_RS14460 (MWH18_14460) 2940926..2944048 - 3123 WP_087537451.1 SIR2 family protein -
MWH18_RS14465 (MWH18_14465) 2944226..2945290 - 1065 WP_087537450.1 macro domain-containing protein Antitoxin
MWH18_RS14470 (MWH18_14470) 2945287..2945946 - 660 WP_087537449.1 DUF4433 domain-containing protein Toxin
MWH18_RS14475 (MWH18_14475) 2946081..2946725 - 645 WP_201798794.1 hypothetical protein -
MWH18_RS14480 (MWH18_14480) 2947485..2947742 + 258 WP_087537452.1 hypothetical protein -
MWH18_RS21665 2947746..2947874 + 129 WP_267285583.1 hypothetical protein -
MWH18_RS14485 (MWH18_14485) 2947878..2948102 + 225 WP_087537448.1 hypothetical protein -
MWH18_RS14490 (MWH18_14490) 2948132..2948635 + 504 WP_087537447.1 hypothetical protein -
MWH18_RS14495 (MWH18_14495) 2948870..2949082 + 213 WP_087537446.1 hypothetical protein -
MWH18_RS14500 (MWH18_14500) 2949200..2949589 + 390 WP_087537445.1 hypothetical protein -
MWH18_RS14505 (MWH18_14505) 2949592..2950059 + 468 WP_087537444.1 hypothetical protein -
MWH18_RS14510 (MWH18_14510) 2950116..2950871 + 756 WP_087537443.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2940926..2953349 12423


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(18-218)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 220 a.a.        Molecular weight: 25369.84 Da        Isoelectric Point: 6.0143

>T241910 WP_087537449.1 NZ_CP095407:c2945946-2945287 [Acinetobacter pittii]
MTEREYSESLNPQKALIWRIVHLDNIAWVLEHGLHCGNSLTASPNWVHIGNTELIDKRANHPVPVGQGGYLNDYVPFYFT
PFSPMLLNITTGRGGVRQRSNDEIVILVSSLHRLQELNMPFVFTDGHAYYQWSNFYTDLADLDKIDWQILQKKDFSRDVD
DPAKFERYQAEALVHQHCPIEALLGMICYNEKIKSLLEQQLQQANIEMPVYVRSGVYFK

Download         Length: 660 bp

>T241910 NZ_OU659204:2607175-2607543 [Providencia alcalifaciens]
ATGGTAAAAGCAAAAAGGCCTCACAAAGGCCAGATTTGGCACATTAATGGCGATCCAGTCGCAGGCAAGGAATTCAAGGG
ACCCCACTACTATTTAGTGGTTACAGATGCACAAATCAACACCGCACTTGGTACGTCAATTTGTGTTCCTATTACAAGTG
GAGGGAGCCGCGCCAGAACTCAAAATGTCACTGTTTACTTAGATGGTTCAAGTACAGATACAGGTAACATTACTGGCTGT
ATCTTATGTTATCAACTCCGCTCGTTAGATCTAATAGCCAGAAAAGCCACTTACTCAGCAACACTCAATGAAGATATTTT
CGAAGAGGTTCTCAGCAATATTATTGATATCATTGACCCTCAAATTTGA

Antitoxin


Download         Length: 355 a.a.        Molecular weight: 40155.14 Da        Isoelectric Point: 5.3205

>AT241910 WP_087537450.1 NZ_CP095407:c2945290-2944226 [Acinetobacter pittii]
MIRYTTGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPDNMAAYRQACKEGRVQTGKMFVTETNEFLAPRWIVNFPTK
QHWKAKSQIEWVEDGLKDLKQFIIEKNISSIAIPPLGAGNGGLDWQDVKPKIESALSDLLDVDVLIFEPTEKYQNIAKNI
GVQKLTPARALIAELIRRYGVLGMECSILEIQKLAWFLQRVIEKHNLSNELRLDFQANYYGPYAHNLTHLLNALDGSYLK
SDKRIPDCEPLDVIWFNQQEQGKVQSYLNSEAKDFVPALEEAAALIEGFESPFGMELLSTVDWLIYKDGCQPTVESIKDG
LANWSAGKRWADRKLSLFKDEHIEYALDKLQKSI

Download         Length: 1065 bp

>AT241910 NZ_OU659204:2606912-2607175 [Providencia alcalifaciens]
ATGTCAACAACCAAATTAAGGCAGCAAGGCGGAGCTGTTGTTTTAACTATCCCAATTGAAGTCGCCAATATGGCTGGATG
GGTCGTCGGTATGAAATTAAATATTGATGCTGTTGGAGAATCCATTTGCATAAAACCGGTCAAACGCGTGGCTAGAGGAA
GAAAATCTATTAATGAGCTACTATCCGGTATTGCTAAAGAAGAGATTAAGTTATTAAACAGTGAAGTCGATGATTCTGAC
CCACAGGGAAATGAGATTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References