Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1294079..1294755 Replicon chromosome
Accession NZ_CP095407
Organism Acinetobacter pittii strain TCM

Toxin (Protein)


Gene name hicA Uniprot ID A0A829SCE7
Locus tag MWH18_RS06330 Protein ID WP_031968589.1
Coordinates 1294079..1294261 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A829S8Y7
Locus tag MWH18_RS06335 Protein ID WP_031968590.1
Coordinates 1294351..1294755 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWH18_RS06275 (MWH18_06270) 1289238..1289837 + 600 WP_228156025.1 HeH/LEM domain protein -
MWH18_RS06280 (MWH18_06275) 1289841..1290218 + 378 WP_057090125.1 hypothetical protein -
MWH18_RS06285 (MWH18_06280) 1290218..1290586 + 369 WP_106466545.1 glutamate 5-kinase -
MWH18_RS06290 (MWH18_06285) 1290586..1290756 + 171 WP_171304438.1 hypothetical protein -
MWH18_RS06295 (MWH18_06290) 1290768..1291181 + 414 WP_049069240.1 hypothetical protein -
MWH18_RS06300 (MWH18_06295) 1291147..1291515 + 369 WP_057090139.1 hypothetical protein -
MWH18_RS06305 (MWH18_06300) 1291517..1291915 + 399 WP_049069242.1 phage tail terminator-like protein -
MWH18_RS06310 (MWH18_06305) 1291917..1292129 + 213 WP_049069243.1 hypothetical protein -
MWH18_RS06315 (MWH18_06310) 1292238..1293167 + 930 WP_031968587.1 phage tail tube protein -
MWH18_RS06320 (MWH18_06315) 1293214..1293747 + 534 WP_031968588.1 hypothetical protein -
MWH18_RS06325 (MWH18_06320) 1293750..1294010 + 261 WP_032042280.1 hypothetical protein -
MWH18_RS06330 (MWH18_06325) 1294079..1294261 + 183 WP_031968589.1 type II toxin-antitoxin system HicA family toxin Toxin
MWH18_RS06335 (MWH18_06330) 1294351..1294755 + 405 WP_031968590.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MWH18_RS06340 (MWH18_06335) 1294837..1295436 + 600 WP_031968591.1 hypothetical protein -
MWH18_RS06345 (MWH18_06340) 1295561..1299634 + 4074 WP_068549413.1 tape measure protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1265276..1321673 56397


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6690.86 Da        Isoelectric Point: 10.7364

>T241909 WP_031968589.1 NZ_CP095407:1294079-1294261 [Acinetobacter pittii]
VKSLDLIKMIEADGWYQVRVTGSHHHFKHPTKKGLVTVPHPKKDLPSGTVKSILKQAGLH

Download         Length: 183 bp

>T241909 NZ_OU659204:c1450309-1449809 [Providencia alcalifaciens]
ATGTATTCAGAGGAAATCGACTATGATTTAACACATTTTGATTGCGGTGAGCCCTATATGAATACGTTTCTCACCGAACA
TTTAAAACGGCAGCATAAAAACCAAGTTTTACGTGGGTATATGCTGTTAACCAAAGAAGAAAAGCCGCGTGTGATGGGCT
ACTACACCTTATCTGGAAGTAGTTTTGAAAAAAGAACGTTGCCAAGCCGTCAGCGACAGATAATGGTGCCTTCCGAAAGT
GCACCCAGTGTCACACTCGGTCGTTTAGCTATTGATAAAAGTATTCAACGACAAGGTTATGGTGAGTTACTCGTTGTTCA
TGCAATGAGAGTTGTCTATCAAGCATCGCATGCAGTGGGTATTTACGGGCTGTTTGTCGAGGCCTTAAATGATAAAGCTA
AACAATTTTATCTCGGACTCGGTTTTATCCAATTAACAGGAGAAAACGCTGCTAGCTTTTTTTATCCAACAAAATCCATT
GAAACGCTTTTTGATATGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.73 Da        Isoelectric Point: 4.3246

>AT241909 WP_031968590.1 NZ_CP095407:1294351-1294755 [Acinetobacter pittii]
MLYPIAIEMGSDTEAFGVIVPDIPGCHSAGDTLEEALDNIKEAIAGHLEILAEDGEEIPLASSVRKFMDLPEYDGMVWFV
TEVDLGRYLGTPEKINVSLPSRLIRKIDDSVGKDKQYKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT241909 NZ_OU659204:c1450603-1450331 [Providencia alcalifaciens]
ATGTTAGCCCCCAAAACCAAACGAATCGACTTAAGACTTAATGAAGAGGACAAAAACTTGATTGAAGAAGCTGCCGCAAT
TACCAACCTGTCTATATCTCAGTTCATGATTAATATTGCATCAGAACGAGCCAGTGAAATTGTCAATCACCATCGACGCC
TCATCCTGAACGAGAATTCATGGGATTTAGTTCAAAATGCTATCAATAACCCTCCAGCTGTAAATAACCGCTTGAAGCAA
GCTGCCAAACGTCTACAAGACACGGAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829SCE7

Antitoxin

Source ID Structure
AlphaFold DB A0A829S8Y7

References