Detailed information of TA system TA241908

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 478914..479567
• Replicon: chromosome
• Accession: NZ_CP095407
• Organism: Acinetobacter pittii strain TCM

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MWH18_RS02380
• Protein ID: WP_126117471.1
• Coordinates: 479178..479567 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A009HHW9
• Locus tag: MWH18_RS02375
• Protein ID: WP_002117064.1
• Coordinates: 478914..479171 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MWH18_RS02355 (MWH18_02355)	474427..475434	+	1008	WP_002116730.1	DNA-directed RNA polymerase subunit alpha	-
MWH18_RS02360 (MWH18_02360)	475453..475830	+	378	WP_002049717.1	50S ribosomal protein L17	-
MWH18_RS02365 (MWH18_02365)	476012..477502	+	1491	WP_032057377.1	NAD(P)/FAD-dependent oxidoreductase	-
MWH18_RS02370 (MWH18_02370)	477553..478725	-	1173	WP_032057378.1	acyl-CoA dehydrogenase family protein	-
MWH18_RS02375 (MWH18_02375)	478914..479171	+	258	WP_002117064.1	succinate dehydrogenase assembly factor 2	Antitoxin
MWH18_RS02380 (MWH18_02380)	479178..479567	+	390	WP_126117471.1	hypothetical protein	Toxin
MWH18_RS02385 (MWH18_02385)	480338..481426	+	1089	WP_032057381.1	hypothetical protein	-
MWH18_RS02390 (MWH18_02390)	481511..482086	+	576	WP_005078319.1	rhombosortase	-
MWH18_RS02395 (MWH18_02395)	482266..484476	+	2211	WP_126117472.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15437.54 Da
• Isoelectric Point: 6.2694

>T241908 WP_126117471.1 NZ_CP095407:479178-479567 [Acinetobacter pittii]
MIKELNFELKYSRVSVIFQLFVGLGLAILLYQLLTPIWWLCAVILLFIGFIFFLKQAQISQIEYLDQKLWSVAYFSKKEI
YCGEITKIIDYQLFVVIYLEETPTNIAIVWFDQLPIQQWIRLKVLEKLY

Nucleotide

• Length: 390 bp

>T241908 NZ_OU659204:c1450309-1449809 [Providencia alcalifaciens]
ATGTATTCAGAGGAAATCGACTATGATTTAACACATTTTGATTGCGGTGAGCCCTATATGAATACGTTTCTCACCGAACA
TTTAAAACGGCAGCATAAAAACCAAGTTTTACGTGGGTATATGCTGTTAACCAAAGAAGAAAAGCCGCGTGTGATGGGCT
ACTACACCTTATCTGGAAGTAGTTTTGAAAAAAGAACGTTGCCAAGCCGTCAGCGACAGATAATGGTGCCTTCCGAAAGT
GCACCCAGTGTCACACTCGGTCGTTTAGCTATTGATAAAAGTATTCAACGACAAGGTTATGGTGAGTTACTCGTTGTTCA
TGCAATGAGAGTTGTCTATCAAGCATCGCATGCAGTGGGTATTTACGGGCTGTTTGTCGAGGCCTTAAATGATAAAGCTA
AACAATTTTATCTCGGACTCGGTTTTATCCAATTAACAGGAGAAAACGCTGCTAGCTTTTTTTATCCAACAAAATCCATT
GAAACGCTTTTTGATATGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10295.73 Da
• Isoelectric Point: 4.4809

>AT241908 WP_002117064.1 NZ_CP095407:478914-479171 [Acinetobacter pittii]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Nucleotide

• Length: 258 bp

>AT241908 NZ_OU659204:c1449665-1449429 [Providencia alcalifaciens]
ATGACGGTAGCCAATAAAATGAAAAAGACGGTGAGTGTGACAGTCTCCCCTGAACTTTATGAACAAGCGAGAAAAGCCAA
TTTGAATTTCTCCCTCGTGTTATCCAATGCTTTACTGGCTGAACTCAAAAAACTTGAGGCGTTAAAATGGAAAGCGGATA
ACCAAGATGGTTTTCAGGAACTCAATAGGATCAGTGAAGAATATGGAATTTTTTCAGAGGAATATAAGGAGCTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A009HHW9