Detailed information of TA system TA241894

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pmenTA/darT(toxin)
• Location: 3473934..3475648
• Replicon: chromosome
• Accession: NZ_CP095280
• Organism: Aeromonas hydrophila strain Ah2111

Toxin (Protein)

• Gene name: pmenT
• Uniprot ID: -
• Locus tag: MUW98_RS15965
• Protein ID: WP_171275904.1
• Coordinates: 3474995..3475648 (-)
• Length: 218 a.a.

Antitoxin (Protein)

• Gene name: pmenA
• Uniprot ID: -
• Locus tag: MUW98_RS15960
• Protein ID: WP_247141495.1
• Coordinates: 3473934..3474959 (-)
• Length: 342 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUW98_RS15950 (MUW98_15950)	3470015..3470728	-	714	WP_125117287.1	SprT family zinc-dependent metalloprotease	-
MUW98_RS15955 (MUW98_15955)	3470728..3473859	-	3132	WP_247141496.1	HsdR family type I site-specific deoxyribonuclease	-
MUW98_RS15960 (MUW98_15960)	3473934..3474959	-	1026	WP_247141495.1	macro domain-containing protein	Antitoxin
MUW98_RS15965 (MUW98_15965)	3474995..3475648	-	654	WP_171275904.1	DUF4433 domain-containing protein	Toxin
MUW98_RS15970 (MUW98_15970)	3475925..3477304	-	1380	WP_247141494.1	restriction endonuclease subunit S	-
MUW98_RS15975 (MUW98_15975)	3477304..3479751	-	2448	WP_247141492.1	type I restriction-modification system subunit M	-
MUW98_RS15980 (MUW98_15980)	3479937..3480383	-	447	WP_247141491.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3446659..3490044	43385

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• ssDNA thymidine ADP-ribosyltransferase, DarT (17-216)

Antitoxin

• Macro domain (5-118)

Sequences

Toxin

Protein

• Length: 218 a.a.
• Molecular weight: 25304.86 Da
• Isoelectric Point: 6.8260

>T241894 WP_171275904.1 NZ_CP095280:c3475648-3474995 [Aeromonas hydrophila]
MAYDYSQSLNPQKALIFRIVHRDNLEWILTHGLWAGNGQQQNPHWVHIGLPELIAKRARHPVPLAPYGVLNDYVPFYFTP
FSPMLSNIHSGRGVPQRENDEILILVSSLHRMAELGLPFVFTDSHAYYQWANFYVDLGDLGRIDWPLLQRRDFKRDAEDL
SKLERYQAEALIHQHCPIEALLGVVCYNEEIKNSVEQCMNRVGVSRPVYVRDGWYFR

Nucleotide

• Length: 654 bp

>T241894 NZ_OU659150:4007257-4007517 [Providencia alcalifaciens]
ATGAGTAGACTTCTAACATGGACGGATCAAGCTTGGGAAGACTATCTATACTGGCAAAACCAAGATAAAAAGACATTAAA
GCGGATAAATAAACTCATTGAAGACACGAAAAGAACGCCATTCAGCGGTATAGGTAAACCAGAGCCACTAAAAGAAAACT
TGGCTGGCTTCTGGTCTCGTAGAATAGATGAAACAAACAGGCTAGTTTATGCAATCGAAAATACCGCATTAGTTATCATT
GCCTGCCGCTATCACTACTGA

Antitoxin

Protein

• Length: 342 a.a.
• Molecular weight: 38225.15 Da
• Isoelectric Point: 6.8634

>AT241894 WP_247141495.1 NZ_CP095280:c3474959-3473934 [Aeromonas hydrophila]
VEALVNTVNTVGVMGKGIALMFKERFPANMRAYAEACKQGDVVTGKMFITQTGELLGPRWIVNFPTKQHWRNPAQMAWIQ
EGLQDLRAWLQAQQVSSIAIPPLGAGNGGLPWPEVKQAIETALGDLDIDILLYEPSRQYQNVAKRGGVAELTPARALIAE
LVRRYWFLGMECSLLEIQKLAWFLARVIGRNPLGDPLQLQFKAHRYGPYANNLTHLLNAMDGSYLQSDKRIPDSKPFDVI
WFNEAKKQELAVYLQTEAKAFLPILEQTTALIDGFESPYGMELLATVDWLIAEEGCAPTLSALREGLHRWPAGTPWGERK
ARLFDDRSLQIALTRLQQGLV

Nucleotide

• Length: 1026 bp

>AT241894 NZ_OU659150:4007010-4007264 [Providencia alcalifaciens]
ATGAAAACCATTTCCTTTAGTGATGCTAGAAGCAATTTGAAAGCAGTGCTTGATAGAGTTGTTGATGATATGGATACGAC
GATTATAACCCGCCGTGATTCTGAAGCGGCTGTAGTTATGTCCTTGGAATACTACAATAGTTTAATGGAAACCATCTATC
TACTGCGCTCTCCTGCAAATGCAGAGCATCTCAACAAATCCATCGAGCAATTTAAAGCGGGTAAGATTTCAGAGAGAAAG
CTAATCAATGAGTAG