Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4635051..4635655 Replicon chromosome
Accession NZ_CP095276
Organism Enterobacter hormaechei subsp. xiangfangensis strain HD8642

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag MU851_RS22245 Protein ID WP_071788668.1
Coordinates 4635470..4635655 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2G4ZRB5
Locus tag MU851_RS22240 Protein ID WP_023295606.1
Coordinates 4635051..4635455 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU851_RS22225 (MU851_22195) 4630591..4631409 - 819 WP_032649828.1 helix-turn-helix domain-containing protein -
MU851_RS22230 (MU851_22200) 4631635..4633035 + 1401 WP_047062387.1 MFS transporter -
MU851_RS22235 (MU851_22205) 4633046..4634995 + 1950 WP_047062388.1 glycoside hydrolase family 127 protein -
MU851_RS22240 (MU851_22210) 4635051..4635455 - 405 WP_023295606.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MU851_RS22245 (MU851_22215) 4635470..4635655 - 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
MU851_RS22250 (MU851_22220) 4635905..4637443 - 1539 WP_006808612.1 aldehyde dehydrogenase AldB -
MU851_RS22255 (MU851_22225) 4637610..4638494 + 885 WP_015572761.1 ROK family protein -
MU851_RS22260 (MU851_22230) 4638498..4640336 - 1839 WP_047062389.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T241888 WP_071788668.1 NZ_CP095276:c4635655-4635470 [Enterobacter hormaechei subsp. xiangfangensis]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T241888 NZ_OU659133:c37025-36081 [Providencia alcalifaciens]
ATGGATAGAGACAGTCCTTACTATAAGCAAGTTTCTCTGCTTATTAAAATACTACCCGTCATAGCAACAGAGCCAACATT
CGCACTTAAAGGCGGCACTGCTATAAATTTATTTGTGAGGAATTTTCCTCGTCTATCAGTAGATATTGATCTCGCCTATC
TTCCATTAGAGTCCAGAAATGATGCACTAGTAAATGTTAAAGCTTCGCTTCTACGGATCACTGATTTAATTAATACTCAA
GTTGATACTCGGGCTGTGTTACAAGACCATAAAGTCGATGAGCTTCGTATTATTGTTAATAGCCCAGGTGGCACTATAAA
GGTTGAGGTATCTCCCGTTGCTAGAGGAGCTTTACATCAACCGAGCATTTTATCCGTACAACCGTCAGTTGAAGATGAAT
TTGGCTATGCAGAAATTCAAGTGGTTAGCCTCCCTGATCTCTATGGCGGTAAGTTATGCGCTGCAATGGATCGCCAACAT
CCTCGCGATTTGTTTGATGTTCGTATGTTGCTTGCAGAGGAGGGAATATCCCGAGATATTTTTGTCGGTTTTTTAACTTA
TGTACTAAGTCATCCAAGACCGATTAATGAGGTTATGGATCCTAACTGGAAGCCACTTGATGAGATATTTCAAACAGAAT
TTGATGGAATGACTTTGGTCAACATTGAACTTGAAGATTTGATTGAGGTAAGATCTGCAATGATGACTGCATTACAGGCT
CATTTCACTGAAAAAGATCGCGTATTTTTGTTATCTTTTAAGCAAGGAAACCCTGATTGGGCACTATTTGACTATCCTAG
TGCTGAAGGGTTGCCAGCAATACGTTGGAAATTACAAAATATCGCGCAATTAGCTAAAAATCGGGATAAATATACAGAGC
AGCTATCTAAATTAGAGGTGGTGCTTGATAGGTGGCTTCACTCAGCGGATAAACAGAGATTGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14954.71 Da        Isoelectric Point: 4.2329

>AT241888 WP_023295606.1 NZ_CP095276:c4635455-4635051 [Enterobacter hormaechei subsp. xiangfangensis]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT241888 NZ_OU659133:c37809-37039 [Providencia alcalifaciens]
ATGTCATCTAAAATAAACTGGTTGGTTACTCATACATATCCAGGCTCGATTGTTTTACAGCAATGGCTGACTAAGAACGG
GATAAGTTACTCCTTAGCTCAAAAGTATACGCAAAGTGGCTGGCTGAAAAAGTTATCTTCAGGTGTTTACTTCCGACCTG
ATGGAAAAGATGGCACCAAACCAGATTGGGTCGATGCCTTGCAAGCGATAAATATTCAGCAGTGTCTTCCTGTTCATTTG
GCGGGATTAAGTAGTTTAAATCACCAAGGATTGAGCCATTATCTACAGCTAAGAAAAGAACAGCTTTGGATTGGCATTAA
AAGTAAGCAGTCATTACCAAAATGGTTTCGAGAGTTTCCTAACCAAGATTGGTTTTATTGTGGTAATTCTAAATTGCAAA
TAGACCCTGACATGGATTTGAAATTCATTACAGTTAAAGGAAAAGAGTTGCTAGTCAGTCGTTCTGAACTTGCGGCTTAT
GAAGTTGTTGATGCAATAGGTAAGCAAATATCGTTTGAGCATGTTGCTGAGCTTTTTCAAGGGCTAGTAAACCTTAGTCC
TAAAAGGGTGCAATCCTTACTTGAGCGAAGTCATGCCATTCAAACCAACCGAATATTCTTGTTTCTTAGTCATCACTGCG
ACCATCAATGGGGAGAATACCTTAATGAAAAAAACATCGAATTAGGATCAGGAAAGCGCCAGGTTGTAAATAAAGGTCGG
CTTGATGAGCGTTATCAAATCACTGTGCCTGAATCACTGAAGACAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4ZRB5

References