Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3959519..3960176 Replicon chromosome
Accession NZ_CP095276
Organism Enterobacter hormaechei subsp. xiangfangensis strain HD8642

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag MU851_RS18980 Protein ID WP_017382887.1
Coordinates 3959519..3959929 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag MU851_RS18985 Protein ID WP_003863437.1
Coordinates 3959910..3960176 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU851_RS18960 (MU851_18930) 3955517..3957250 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
MU851_RS18965 (MU851_18935) 3957256..3957969 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MU851_RS18970 (MU851_18940) 3957998..3958894 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
MU851_RS18975 (MU851_18945) 3958996..3959517 + 522 WP_015571793.1 flavodoxin FldB -
MU851_RS18980 (MU851_18950) 3959519..3959929 - 411 WP_017382887.1 protein YgfX Toxin
MU851_RS18985 (MU851_18955) 3959910..3960176 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
MU851_RS18990 (MU851_18960) 3960471..3961451 + 981 WP_017692714.1 tRNA-modifying protein YgfZ -
MU851_RS18995 (MU851_18965) 3961563..3962222 - 660 WP_003863433.1 hemolysin III family protein -
MU851_RS19000 (MU851_18970) 3962489..3963220 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
MU851_RS19005 (MU851_18975) 3963337..3964770 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T241887 WP_017382887.1 NZ_CP095276:c3959929-3959519 [Enterobacter hormaechei subsp. xiangfangensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T241887 NZ_OU659132:146934-147212 [Providencia alcalifaciens]
ATGATAAAATCGTTTAAACATAAAGGGTTGAAACAACTCTTTGAAAAAGGAATAACTTCAGGGGTTCCGGCTCAAGATGC
TGAACGGATCAACGACCGTTTACAAGCAATAGATATCGCTAACGATATTCGTGAATTAGACCGCCAAATTTACAAATTGC
ATCCACTGAAAGGTGACAGAGAAGGTTATTGGTCAATAACAGTGCGAGCGAATTGGCGCATTACTTTTCAATTCATCAAT
GGTGATGCTTACATCTTAAATTATGAGGATTATCACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT241887 WP_003863437.1 NZ_CP095276:c3960176-3959910 [Enterobacter hormaechei subsp. xiangfangensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT241887 NZ_OU659132:147212-147526 [Providencia alcalifaciens]
ATGAGACAGTTTAAAATATCTCACCCAGGTGAAATTATTGCACGAGATTTGGCTGATATGGGGATCAGTGGTCGACGTTT
TGCATTAAATATTGGTGTAACGCCAGCAACAGTTTCCCGTTTTTTATCAGGTAAAACAGCATTGACTCCCGCATTGGCAA
TCCGTATCGCCGCTGCACTAGGAAGTACTCCTGAATTTTGGTTACGTTTACAAAGTGCTTATGATTTACGTCAATTAGAA
AATCAAATTGATACGTCCGATATTATTTTGTATGAAGAGGCGCCTGATAGCGCTAAAGGCATATCCAAACATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References