Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA(toxin) |
| Location | 3153258..3155041 | Replicon | chromosome |
| Accession | NZ_CP095276 | ||
| Organism | Enterobacter hormaechei subsp. xiangfangensis strain HD8642 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | MU851_RS15035 | Protein ID | WP_063136628.1 |
| Coordinates | 3153258..3154607 (+) | Length | 450 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A2G5A843 |
| Locus tag | MU851_RS15040 | Protein ID | WP_045333654.1 |
| Coordinates | 3154604..3155041 (+) | Length | 146 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MU851_RS15010 (MU851_14980) | 3149081..3150016 | - | 936 | WP_015572323.1 | tRNA dihydrouridine(16) synthase DusC | - |
| MU851_RS15015 (MU851_14985) | 3150185..3150580 | + | 396 | WP_032671768.1 | CidA/LrgA family protein | - |
| MU851_RS15020 (MU851_14990) | 3150577..3151272 | + | 696 | WP_015572322.1 | CidB/LrgB family autolysis modulator | - |
| MU851_RS15025 (MU851_14995) | 3151401..3152285 | + | 885 | WP_032671769.1 | cytidine deaminase | - |
| MU851_RS15030 (MU851_15000) | 3152413..3153123 | + | 711 | WP_017383381.1 | outer membrane permeability protein SanA | - |
| MU851_RS15035 (MU851_15005) | 3153258..3154607 | + | 1350 | WP_063136628.1 | HipA domain-containing protein | Toxin |
| MU851_RS15040 (MU851_15010) | 3154604..3155041 | + | 438 | WP_045333654.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MU851_RS15045 (MU851_15015) | 3155080..3156090 | - | 1011 | WP_003859318.1 | galactose/methyl galactoside ABC transporter permease MglC | - |
| MU851_RS15050 (MU851_15020) | 3156106..3157626 | - | 1521 | WP_003859320.1 | galactose/methyl galactoside ABC transporter ATP-binding protein MglA | - |
| MU851_RS15055 (MU851_15025) | 3157706..3158704 | - | 999 | WP_017383382.1 | galactose/glucose ABC transporter substrate-binding protein MglB | - |
| MU851_RS15060 (MU851_15030) | 3159000..3160022 | - | 1023 | WP_003859324.1 | HTH-type transcriptional regulator GalS | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 450 a.a. Molecular weight: 51211.86 Da Isoelectric Point: 4.6594
>T241885 WP_063136628.1 NZ_CP095276:3153258-3154607 [Enterobacter hormaechei subsp. xiangfangensis]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVECNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRTLINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPTT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVECNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRTLINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPTT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL
Download Length: 1350 bp
>T241885 NZ_OU659131:c283770-283567 [Providencia alcalifaciens]
ATGACCAAATCCGATTATCTGATGCGTTTAAGAAAATGCACCACTATTGAAACACTTGAGCGCGTTATTGAAAAAAATAA
GTATGAGTTATCCGATGATGAGTTAGAGTTATTTTACTCTGCCGCTGATCATCGTCTTGCAGAGCTCACGATGAATAAAC
TTTACGATAAAATTCCAGCATCTGTTTGGAAGTTTGTTAGATAA
ATGACCAAATCCGATTATCTGATGCGTTTAAGAAAATGCACCACTATTGAAACACTTGAGCGCGTTATTGAAAAAAATAA
GTATGAGTTATCCGATGATGAGTTAGAGTTATTTTACTCTGCCGCTGATCATCGTCTTGCAGAGCTCACGATGAATAAAC
TTTACGATAAAATTCCAGCATCTGTTTGGAAGTTTGTTAGATAA
Antitoxin
Download Length: 146 a.a. Molecular weight: 16171.61 Da Isoelectric Point: 10.5154
>AT241885 WP_045333654.1 NZ_CP095276:3154604-3155041 [Enterobacter hormaechei subsp. xiangfangensis]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEDPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEDPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS
Download Length: 438 bp
>AT241885 NZ_OU659131:c284211-283843 [Providencia alcalifaciens]
ATGGATGAATACTCACCCAAGAAACATGATATAGCCGAATTAAAATATCTTTGTAACAGTTTGAATAGAGACGCTATATC
AAGTTTACAAAAAACAAACACTCATTGGATAAATGATCTTAGTTCTGCACAAAGCATCAGTCTTAACGAGCTTGTTGAGC
ATATTGCAGCTTTTGTCTGGCGATTTAAAATCAAATATCCAAAAGAAAATCTCGTTATTTCTCTTGTTGAAGAGTATCTT
GACGAAACATATAATTTATTTGGCAGCCCAGTAGTTACCTTCAGCGAAATCATTGACTGGGAAAGTATGAATCAAAATCT
TGTCGCCGTGCTCGATGATGATCTAAAATGTCTGACAAGTAAGACTTAG
ATGGATGAATACTCACCCAAGAAACATGATATAGCCGAATTAAAATATCTTTGTAACAGTTTGAATAGAGACGCTATATC
AAGTTTACAAAAAACAAACACTCATTGGATAAATGATCTTAGTTCTGCACAAAGCATCAGTCTTAACGAGCTTGTTGAGC
ATATTGCAGCTTTTGTCTGGCGATTTAAAATCAAATATCCAAAAGAAAATCTCGTTATTTCTCTTGTTGAAGAGTATCTT
GACGAAACATATAATTTATTTGGCAGCCCAGTAGTTACCTTCAGCGAAATCATTGACTGGGAAAGTATGAATCAAAATCT
TGTCGCCGTGCTCGATGATGATCTAAAATGTCTGACAAGTAAGACTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|