Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2378451..2379190 Replicon chromosome
Accession NZ_CP095276
Organism Enterobacter hormaechei subsp. xiangfangensis strain HD8642

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag MU851_RS11345 Protein ID WP_003857133.1
Coordinates 2378451..2378936 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag MU851_RS11350 Protein ID WP_003857131.1
Coordinates 2378924..2379190 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU851_RS11325 (MU851_11305) 2373868..2374629 + 762 WP_001176973.1 hypothetical protein -
MU851_RS11330 (MU851_11310) 2375147..2376187 - 1041 WP_252055383.1 hypothetical protein -
MU851_RS11335 (MU851_11315) 2376850..2377815 + 966 WP_058689390.1 hypothetical protein -
MU851_RS11340 (MU851_11320) 2377831..2378400 + 570 WP_032648331.1 hypothetical protein -
MU851_RS11345 (MU851_11325) 2378451..2378936 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
MU851_RS11350 (MU851_11330) 2378924..2379190 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
MU851_RS11355 (MU851_11335) 2379254..2380183 - 930 WP_063136309.1 LysR family transcriptional regulator -
MU851_RS11360 (MU851_11340) 2380313..2381695 + 1383 WP_063136310.1 MFS transporter -
MU851_RS11365 (MU851_11345) 2381717..2382712 - 996 WP_063136311.1 DUF2891 domain-containing protein -
MU851_RS11370 (MU851_11350) 2382722..2383708 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2373371..2373763 392


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T241875 WP_003857133.1 NZ_CP095276:c2378936-2378451 [Enterobacter hormaechei subsp. xiangfangensis]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T241875 NZ_OU659122:c66254-65976 [Providencia alcalifaciens]
ATGGAATTAAAATGGACGAGTAAGGCATTATCGGATCTTTCTCGTGTATATGATTTTTTAGCGTTATCAAACTCAGTCGC
TGCCGCGCGTGTTGTGCAAACATTGACGAAAGCCCCCATGTTGTTGTTGATAAAAAACCCCCGAATGGGAGAGCAATTGT
TTCAATTTATGCCACACGAAGTCCGTCGGATTGTGGTGGTGAATTATGAGATACGTTATGAACTCATTGATTCGACAATC
TATATTTTACGGATATGGCATACACGAGAAGATCGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT241875 WP_003857131.1 NZ_CP095276:c2379190-2378924 [Enterobacter hormaechei subsp. xiangfangensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT241875 NZ_OU659122:c65976-65833 [Providencia alcalifaciens]
ATGAGACAATTTAAAGTATCTCACCTTGGTGAAATTATCGCTAGAGACTTGGCTGATATGGGGATTAGTGGTCGACGTTT
CGCGCTCAATATTGATGTCACTCCAGCGACCGCTGGCAATTCGAATTGCTGCTGCATTAGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References