Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 1675429..1676226 Replicon chromosome
Accession NZ_CP095276
Organism Enterobacter hormaechei subsp. xiangfangensis strain HD8642

Toxin (Protein)


Gene name KacT Uniprot ID A0A222RDD1
Locus tag MU851_RS07825 Protein ID WP_032647926.1
Coordinates 1675705..1676226 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A331QJY7
Locus tag MU851_RS07820 Protein ID WP_015570876.1
Coordinates 1675429..1675698 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU851_RS07785 (MU851_07775) 1670970..1671329 + 360 WP_017384779.1 helix-turn-helix domain-containing protein -
MU851_RS07790 (MU851_07780) 1671401..1671502 - 102 Protein_1509 transcriptional regulator -
MU851_RS07795 (MU851_07785) 1671655..1672896 + 1242 WP_017693667.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
MU851_RS07800 (MU851_07790) 1672929..1673156 - 228 WP_006809324.1 YccJ family protein -
MU851_RS07805 (MU851_07795) 1673175..1673771 - 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
MU851_RS07810 (MU851_07800) 1674163..1674333 + 171 WP_001273664.1 general stress protein -
MU851_RS07815 (MU851_07805) 1674450..1675355 + 906 WP_063136398.1 DMT family transporter -
MU851_RS07820 (MU851_07810) 1675429..1675698 + 270 WP_015570876.1 DUF1778 domain-containing protein Antitoxin
MU851_RS07825 (MU851_07815) 1675705..1676226 + 522 WP_032647926.1 GNAT family N-acetyltransferase Toxin
MU851_RS07830 (MU851_07820) 1676285..1677607 - 1323 WP_015570874.1 pyrimidine utilization transport protein G -
MU851_RS07835 (MU851_07825) 1677629..1678120 - 492 WP_015570873.1 pyrimidine utilization flavin reductase protein F -
MU851_RS07840 (MU851_07830) 1678133..1678723 - 591 WP_015570872.1 malonic semialdehyde reductase -
MU851_RS07845 (MU851_07835) 1678733..1679533 - 801 WP_015570871.1 pyrimidine utilization protein D -
MU851_RS07850 (MU851_07840) 1679541..1679927 - 387 WP_015570870.1 pyrimidine utilization protein C -
MU851_RS07855 (MU851_07845) 1679939..1680628 - 690 WP_023296288.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19451.21 Da        Isoelectric Point: 7.4318

>T241874 WP_032647926.1 NZ_CP095276:1675705-1676226 [Enterobacter hormaechei subsp. xiangfangensis]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp

>T241874 NZ_OU659122:c37025-36081 [Providencia alcalifaciens]
ATGGATAGAGACAGTCCTTACTATAAGCAAGTTTCTCTGCTTATTAAAATACTACCCGTCATAGCAACAGAGCCAACATT
CGCACTTAAAGGCGGCACTGCTATAAATTTATTTGTGAGGAATTTTCCTCGTCTATCAGTAGATATTGATCTCGCCTATC
TTCCATTAGAGTCCAGAAATGATGCACTAGTAAATGTTAAAGCTTCGCTTCTACGGATCACTGATTTAATTAATACTCAA
GTTGATACTCGGGCTGTGTTACAAGACCATAAAGTCGATGAGCTTCGTATTATTGTTAATAGCCCAGGTGGCACTATAAA
GGTTGAGGTATCTCCCGTTGCTAGAGGAGCTTTACATCAACCGAGCATTTTATCCGTACAACCGTCAGTTGAAGATGAAT
TTGGCTATGCAGAAATTCAAGTGGTTAGCCTCCCTGATCTCTATGGCGGTAAGTTATGCGCTGCAATGGATCGCCAACAT
CCTCGCGATTTGTTTGATGTTCGTATGTTGCTTGCAGAGGAGGGAATATCCCGAGATATTTTTGTCGGTTTTTTAACTTA
TGTACTAAGTCATCCAAGACCGATTAATGAGGTTATGGATCCTAACTGGAAGCCACTTGATGAGATATTTCAAACAGAAT
TTGATGGAATGACTTTGGTCAACATTGAACTTGAAGATTTGATTGAGGTAAGATCTGCAATGATGACTGCATTACAGGCT
CATTTCACTGAAAAAGATCGCGTATTTTTGTTATCTTTTAAGCAAGGAAACCCTGATTGGGCACTATTTGACTATCCTAG
TGCTGAAGGGTTGCCAGCAATACGTTGGAAATTACAAAATATCGCGCAATTAGCTAAAAATCGGGATAAATATACAGAGC
AGCTATCTAAATTAGAGGTGGTGCTTGATAGGTGGCTTCACTCAGCGGATAAACAGAGATTGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10247.75 Da        Isoelectric Point: 5.8836

>AT241874 WP_015570876.1 NZ_CP095276:1675429-1675698 [Enterobacter hormaechei subsp. xiangfangensis]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp

>AT241874 NZ_OU659122:c37809-37039 [Providencia alcalifaciens]
ATGTCATCTAAAATAAACTGGTTGGTTACTCATACATATCCAGGCTCGATTGTTTTACAGCAATGGCTGACTAAGAACGG
GATAAGTTACTCCTTAGCTCAAAAGTATACGCAAAGTGGCTGGCTGAAAAAGTTATCTTCAGGTGTTTACTTCCGACCTG
ATGGAAAAGATGGCACCAAACCAGATTGGGTCGATGCCTTGCAAGCGATAAATATTCAGCAGTGTCTTCCTGTTCATTTG
GCGGGATTAAGTAGTTTAAATCACCAAGGATTGAGCCATTATCTACAGCTAAGAAAAGAACAGCTTTGGATTGGCATTAA
AAGTAAGCAGTCATTACCAAAATGGTTTCGAGAGTTTCCTAACCAAGATTGGTTTTATTGTGGTAATTCTAAATTGCAAA
TAGACCCTGACATGGATTTGAAATTCATTACAGTTAAAGGAAAAGAGTTGCTAGTCAGTCGTTCTGAACTTGCGGCTTAT
GAAGTTGTTGATGCAATAGGTAAGCAAATATCGTTTGAGCATGTTGCTGAGCTTTTTCAAGGGCTAGTAAACCTTAGTCC
TAAAAGGGTGCAATCCTTACTTGAGCGAAGTCATGCCATTCAAACCAACCGAATATTCTTGTTTCTTAGTCATCACTGCG
ACCATCAATGGGGAGAATACCTTAATGAAAAAAACATCGAATTAGGATCAGGAAAGCGCCAGGTTGTAAATAAAGGTCGG
CTTGATGAGCGTTATCAAATCACTGTGCCTGAATCACTGAAGACAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A222RDD1

Antitoxin

Source ID Structure
AlphaFold DB A0A331QJY7

References