Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1088673..1089293 Replicon chromosome
Accession NZ_CP095276
Organism Enterobacter hormaechei subsp. xiangfangensis strain HD8642

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag MU851_RS05115 Protein ID WP_015571250.1
Coordinates 1088673..1088891 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag MU851_RS05120 Protein ID WP_006809850.1
Coordinates 1088919..1089293 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU851_RS05085 (MU851_05075) 1084685..1084945 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
MU851_RS05090 (MU851_05080) 1084948..1085088 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
MU851_RS05095 (MU851_05085) 1085085..1085795 - 711 WP_023303201.1 GNAT family protein -
MU851_RS05100 (MU851_05090) 1085897..1087357 + 1461 WP_063136483.1 PLP-dependent aminotransferase family protein -
MU851_RS05105 (MU851_05095) 1087329..1087796 - 468 WP_015571252.1 YlaC family protein -
MU851_RS05110 (MU851_05100) 1087913..1088464 - 552 WP_045339381.1 maltose O-acetyltransferase -
MU851_RS05115 (MU851_05105) 1088673..1088891 - 219 WP_015571250.1 HHA domain-containing protein Toxin
MU851_RS05120 (MU851_05110) 1088919..1089293 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
MU851_RS05125 (MU851_05115) 1089804..1092950 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
MU851_RS05130 (MU851_05120) 1092973..1094166 - 1194 WP_063136482.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T241872 WP_015571250.1 NZ_CP095276:c1088891-1088673 [Enterobacter hormaechei subsp. xiangfangensis]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T241872 NZ_OU659121:123021-123302 [Providencia alcalifaciens]
ATGACTTATAAACTTGAATTTGATAGACGGGCGTTAAAAGAATGGCAAAAACTAGCCCCTCCGATTAGAAATCAATTTAA
AAAGAAACTGTTAGAACGTATTGAAAATCCTTGTGTTCCATCAGCTAAACTTAGTGGTAAAAATAATCGTTATAAAATAA
AACTACGATCATTAGGTTACCGCTTAATTTATGAAGTGATAGATGAAAAAATTATTCTGTTAGTCATTGCCGTTGGTAAA
AGAGAGGGTAATACTGTCTATTTTTCATCGAACGAACGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT241872 WP_006809850.1 NZ_CP095276:c1089293-1088919 [Enterobacter hormaechei subsp. xiangfangensis]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT241872 NZ_OU659121:122780-123031 [Providencia alcalifaciens]
ATGACTTATCAAATTTTGAGTGATACTGCTGCGAGCATAACTGACTTGAAGAAAAATCCAATGGGCACTATTGCAGGTGG
TGAAGGGAACCCCGTAGCTATTCTTAATAGAAATGAACCTGCATTTTATTGTGTTCCCCCTGAACTATTTGCTTGGTTCA
TGGAGTTAGCTGAAGATGCTGAACTTAACAAAATTGCAGATGAACGATTAGAATCACTTGATGTAGTGAGTGTGAATATC
GATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References