Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 308778..309374 Replicon chromosome
Accession NZ_CP095276
Organism Enterobacter hormaechei subsp. xiangfangensis strain HD8642

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MU851_RS01465 Protein ID WP_063136798.1
Coordinates 309072..309374 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A927HL08
Locus tag MU851_RS01460 Protein ID WP_023295755.1
Coordinates 308778..309065 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU851_RS01455 (MU851_01455) 307150..308781 + 1632 WP_003860350.1 Na/Pi cotransporter family protein -
MU851_RS01460 (MU851_01460) 308778..309065 - 288 WP_023295755.1 putative addiction module antidote protein Antitoxin
MU851_RS01465 (MU851_01465) 309072..309374 - 303 WP_063136798.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MU851_RS01470 (MU851_01470) 309572..310444 + 873 WP_003860347.1 23S rRNA pseudouridine(2604) synthase RluF -
MU851_RS01475 (MU851_01475) 310445..310717 - 273 WP_017382612.1 DUF3811 domain-containing protein -
MU851_RS01480 (MU851_01480) 310768..311712 - 945 WP_015570166.1 ketopantoate/pantoate/pantothenate transporter PanS -
MU851_RS01485 (MU851_01485) 311806..313155 - 1350 WP_006810501.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11455.21 Da        Isoelectric Point: 10.3736

>T241871 WP_063136798.1 NZ_CP095276:c309374-309072 [Enterobacter hormaechei subsp. xiangfangensis]
MKEIVQTESFRRWEQNLKDRRTKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRIYFKDQGNSIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T241871 NZ_OU659120:3161821-3162024 [Providencia alcalifaciens]
ATGACCAAATCCGATTATCTGATGCGTTTAAGAAAATGCACCACTATTGAAACACTTGAGCGCGTTATTGAAAAAAATAA
GTATGAGTTATCCGATGATGAGTTAGAGTTATTTTACTCTGCCGCTGATCATCGTCTTGCAGAGCTCACGATGAATAAAC
TTTACGATAAAATTCCAGCATCTGTTTGGAAGTTTGTTAGATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10101.59 Da        Isoelectric Point: 5.7807

>AT241871 WP_023295755.1 NZ_CP095276:c309065-308778 [Enterobacter hormaechei subsp. xiangfangensis]
MHKLTPYDPANALLDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp

>AT241871 NZ_OU659120:3161380-3161748 [Providencia alcalifaciens]
ATGGATGAATACTCACCCAAGAAACATGATATAGCCGAATTAAAATATCTTTGTAACAGTTTGAATAGAGACGCTATATC
AAGTTTACAAAAAACAAACACTCATTGGATAAATGATCTTAGTTCTGCACAAAGCATCAGTCTTAACGAGCTTGTTGAGC
ATATTGCAGCTTTTGTCTGGCGATTTAAAATCAAATATCCAAAAGAAAATCTCGTTATTTCTCTTGTTGAAGAGTATCTT
GACGAAACATATAATTTATTTGGCAGCCCAGTAGTTACCTTCAGCGAAATCATTGACTGGGAAAGTATGAATCAAAATCT
TGTCGCCGTGCTCGATGATGATCTAAAATGTCTGACAAGTAAGACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References