Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 32070..32629 Replicon plasmid pEC9682-2
Accession NZ_CP095273
Organism Escherichia coli strain EC9682

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MU524_RS26350 Protein ID WP_000421261.1
Coordinates 32070..32345 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MU524_RS26355 Protein ID WP_001297026.1
Coordinates 32345..32629 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU524_RS26325 (MU524_26335) 27838..28890 + 1053 WP_000655519.1 hypothetical protein -
MU524_RS26330 (MU524_26340) 29066..29668 + 603 WP_000521606.1 ProQ/FINO family protein -
MU524_RS26335 (MU524_26345) 29851..31063 - 1213 Protein_43 IS3 family transposase -
MU524_RS26340 (MU524_26350) 31226..31492 + 267 WP_000627832.1 hypothetical protein -
MU524_RS26345 (MU524_26355) 31761..31964 - 204 Protein_45 hypothetical protein -
MU524_RS26350 (MU524_26360) 32070..32345 - 276 WP_000421261.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MU524_RS26355 (MU524_26365) 32345..32629 - 285 WP_001297026.1 ribbon-helix-helix domain-containing protein Antitoxin
MU524_RS26360 (MU524_26370) 33534..34406 - 873 WP_000729438.1 incFII family plasmid replication initiator RepA -
MU524_RS26365 (MU524_26375) 35244..35750 + 507 WP_005082529.1 transcription termination/antitermination NusG family protein -
MU524_RS26370 (MU524_26380) 35890..36552 + 663 WP_005082527.1 hypothetical protein -
MU524_RS26375 (MU524_26385) 36819..36962 + 144 WP_000176500.1 hypothetical protein -
MU524_RS26380 (MU524_26390) 37043..37285 + 243 WP_021515452.1 PilI type IV pilus biogenesis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-14 - 1..96608 96608


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10735.42 Da        Isoelectric Point: 9.9324

>T241870 WP_000421261.1 NZ_CP095273:c32345-32070 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEVRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T241870 NZ_OU659120:1169443-1169853 [Providencia alcalifaciens]
GTGGTCCTGTGGAAATCTAATCTTTCCATTTCATGGAAAACCCAGCTTTTTTCAACCAGCCTCCATGTGGGGGCGGGTAT
CATTTTGCTTGTTGCACCATGGGAACCTGGTAACTCGATGATTTGGCTTCCATTATTGGTTATCTTAGTGGCGAGCTGGG
CAAAAAGTCAAAAGAACATTAGCAAAGTGAAAGGCGTTGCTGTACTGGTGAATGGCAATAAGCTTCAATGGAAAAAGAAT
GAGTGGGAAATAATCAAAGCACCATGGTGTAGCCGTTGTGGTATTTTATTGACGCTTAAGGCACTGCAAGGAAAGCCACA
GAAGCTGCGTTTGTGGGTGGCGAAAGATTCAGTGTCCGAAGAAAATTGGCGTAACCTCAATCAATTATTACTGCAATATC
CCGACATTTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10502.95 Da        Isoelectric Point: 5.6558

>AT241870 WP_001297026.1 NZ_CP095273:c32629-32345 [Escherichia coli]
MQMKNNTVQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT241870 NZ_OU659120:1169196-1169462 [Providencia alcalifaciens]
ATCGATATCAATAACAAGGCGCGAATTCATTGGGCATGCAGAAGAGGCATGCGTGAGCTTGATATTTCTATCATGCCATT
TTTTGAATATGAATATGACGAACTGACAGATCACGATAAACGTATTTTTGTGCGTCTACTCGAGTGCCCAGATCCAGATT
TGTTCAATTGGTTGATGAATCACGGGCGTCCGGAGGATGAAGAGCTATTCTCTATGATTAAACTCATTCAAGAAAGAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References