Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4650289..4650786 Replicon chromosome
Accession NZ_CP095271
Organism Escherichia coli strain EC9682

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag MU524_RS22910 Protein ID WP_001173343.1
Coordinates 4650289..4650462 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag MU524_RS22915 Protein ID WP_001312331.1
Coordinates 4650490..4650786 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU524_RS22900 (4646959) 4646959..4648416 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
MU524_RS22905 (4648653) 4648653..4650170 + 1518 WP_000003806.1 lysine--tRNA ligase -
MU524_RS22910 (4650289) 4650289..4650462 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
MU524_RS22915 (4650490) 4650490..4650786 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
MU524_RS22920 (4651015) 4651015..4651287 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
MU524_RS22925 (4651299) 4651299..4651529 - 231 WP_000373293.1 4Fe-4S mono-cluster protein YjdI -
MU524_RS22930 (4651710) 4651710..4653341 + 1632 WP_001216482.1 sensor histidine kinase -
MU524_RS22935 (4653338) 4653338..4654057 + 720 WP_000611291.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T241861 WP_001173343.1 NZ_CP095271:c4650462-4650289 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T241861 NZ_OU659115:c37025-36081 [Providencia alcalifaciens]
ATGGATAGAGACAGTCCTTACTATAAGCAAGTTTCTCTGCTTATTAAAATACTACCCGTCATAGCAACAGAGCCAACATT
CGCACTTAAAGGCGGCACTGCTATAAATTTATTTGTGAGGAATTTTCCTCGTCTATCAGTAGATATTGATCTCGCCTATC
TTCCATTAGAGTCCAGAAATGATGCACTAGTAAATGTTAAAGCTTCGCTTCTACGGATCACTGATTTAATTAATACTCAA
GTTGATACTCGGGCTGTGTTACAAGACCATAAAGTCGATGAGCTTCGTATTATTGTTAATAGCCCAGGTGGCACTATAAA
GGTTGAGGTATCTCCCGTTGCTAGAGGAGCTTTACATCAACCGAGCATTTTATCCGTACAACCGTCAGTTGAAGATGAAT
TTGGCTATGCAGAAATTCAAGTGGTTAGCCTCCCTGATCTCTATGGCGGTAAGTTATGCGCTGCAATGGATCGCCAACAT
CCTCGCGATTTGTTTGATGTTCGTATGTTGCTTGCAGAGGAGGGAATATCCCGAGATATTTTTGTCGGTTTTTTAACTTA
TGTACTAAGTCATCCAAGACCGATTAATGAGGTTATGGATCCTAACTGGAAGCCACTTGATGAGATATTTCAAACAGAAT
TTGATGGAATGACTTTGGTCAACATTGAACTTGAAGATTTGATTGAGGTAAGATCTGCAATGATGACTGCATTACAGGCT
CATTTCACTGAAAAAGATCGCGTATTTTTGTTATCTTTTAAGCAAGGAAACCCTGATTGGGCACTATTTGACTATCCTAG
TGCTGAAGGGTTGCCAGCAATACGTTGGAAATTACAAAATATCGCGCAATTAGCTAAAAATCGGGATAAATATACAGAGC
AGCTATCTAAATTAGAGGTGGTGCTTGATAGGTGGCTTCACTCAGCGGATAAACAGAGATTGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT241861 WP_001312331.1 NZ_CP095271:c4650786-4650490 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp

>AT241861 NZ_OU659115:c37809-37039 [Providencia alcalifaciens]
ATGTCATCTAAAATAAACTGGTTGGTTACTCATACATATCCAGGCTCGATTGTTTTACAGCAATGGCTGACTAAGAACGG
GATAAGTTACTCCTTAGCTCAAAAGTATACGCAAAGTGGCTGGCTGAAAAAGTTATCTTCAGGTGTTTACTTCCGACCTG
ATGGAAAAGATGGCACCAAACCAGATTGGGTCGATGCCTTGCAAGCGATAAATATTCAGCAGTGTCTTCCTGTTCATTTG
GCGGGATTAAGTAGTTTAAATCACCAAGGATTGAGCCATTATCTACAGCTAAGAAAAGAACAGCTTTGGATTGGCATTAA
AAGTAAGCAGTCATTACCAAAATGGTTTCGAGAGTTTCCTAACCAAGATTGGTTTTATTGTGGTAATTCTAAATTGCAAA
TAGACCCTGACATGGATTTGAAATTCATTACAGTTAAAGGAAAAGAGTTGCTAGTCAGTCGTTCTGAACTTGCGGCTTAT
GAAGTTGTTGATGCAATAGGTAAGCAAATATCGTTTGAGCATGTTGCTGAGCTTTTTCAAGGGCTAGTAAACCTTAGTCC
TAAAAGGGTGCAATCCTTACTTGAGCGAAGTCATGCCATTCAAACCAACCGAATATTCTTGTTTCTTAGTCATCACTGCG
ACCATCAATGGGGAGAATACCTTAATGAAAAAAACATCGAATTAGGATCAGGAAAGCGCCAGGTTGTAAATAAAGGTCGG
CTTGATGAGCGTTATCAAATCACTGTGCCTGAATCACTGAAGACAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References