Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2092602..2093080 Replicon chromosome
Accession NZ_CP095271
Organism Escherichia coli strain EC9682

Toxin (Protein)


Gene name parE_1 Uniprot ID D8A5B3
Locus tag MU524_RS09995 Protein ID WP_000936799.1
Coordinates 2092602..2092889 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID D8A5B4
Locus tag MU524_RS10000 Protein ID WP_000100899.1
Coordinates 2092889..2093080 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU524_RS09965 (2089121) 2089121..2089342 - 222 WP_000560231.1 cell division protein FtsZ -
MU524_RS09970 (2089388) 2089388..2090236 - 849 WP_000935606.1 Rha family phage regulatory protein -
MU524_RS09975 (2090804) 2090804..2091025 + 222 WP_000202161.1 hypothetical protein -
MU524_RS09985 (2091873) 2091873..2092166 - 294 WP_097494701.1 hypothetical protein -
MU524_RS09990 (2092178) 2092178..2092330 - 153 WP_000379609.1 DUF1391 family protein -
MU524_RS09995 (2092602) 2092602..2092889 - 288 WP_000936799.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MU524_RS10000 (2092889) 2092889..2093080 - 192 WP_000100899.1 hypothetical protein Antitoxin
MU524_RS10005 (2093108) 2093108..2093509 - 402 WP_001329851.1 helix-turn-helix domain-containing protein -
MU524_RS10010 (2093619) 2093619..2093891 + 273 WP_000887447.1 YdaS family helix-turn-helix protein -
MU524_RS10015 (2093875) 2093875..2094300 + 426 WP_000693918.1 toxin YdaT family protein -
MU524_RS10020 (2094372) 2094372..2095442 + 1071 WP_001262355.1 hypothetical protein -
MU524_RS10025 (2095483) 2095483..2095908 + 426 WP_001151152.1 DUF977 family protein -
MU524_RS10030 (2096083) 2096083..2096748 + 666 WP_000150294.1 epoxyqueuosine reductase QueH -
MU524_RS10035 (2096986) 2096986..2097141 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
MU524_RS10040 (2097309) 2097309..2097587 + 279 WP_024193993.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ybtP / ybtQ / ybtX / ybtS 2076187..2130447 54260


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10929.85 Da        Isoelectric Point: 10.1360

>T241837 WP_000936799.1 NZ_CP095271:c2092889-2092602 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENIPAARRLKIRIETSVLALSEHPYLYPPSDRVSGLREIVVHPNYIVLYRVATSSIE
IANIVHARRQFPFPI

Download         Length: 288 bp

>T241837 NZ_OU342919:4451852-4451959 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7035.80 Da        Isoelectric Point: 4.0270

>AT241837 WP_000100899.1 NZ_CP095271:c2093080-2092889 [Escherichia coli]
MSTALSPIVSEFETTEQENSYNEWLRAKVASSLADPRPSIPHDEVMAEMENLIAQIAVTNRSE

Download         Length: 192 bp

>AT241837 NZ_OU342919:c4451802-4451739 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D8A5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A161RC07

References